诱导多能性干细胞研究进展  

Progress in induced pluripotent stem cells

作　　者：刘孟麟[1] 王晓旭[1] 陈贝克[1] 刘运来[1] 

机构地区：[1]第三军医大学组胚教研室,重庆400038

出　　处：《国际生物医学工程杂志》2010年第1期50-53,共4页International Journal of Biomedical Engineering

基　　金：基金项目：重庆市自然科学基金资助项目（CSTC,2007BB5048）

摘　　要：人类诱导多能性干细胞（iPS细胞）的出现被誉为生命科学领域里新的里程碑，它建立了一种全新的、相对易操作而较稳定的体细胞核重编程方法，在生物学基础研究和临床应用方面具有潜在的价值；然而，iPS细胞的高癌变率和极低的重编程效率大大限制了它的应用。目前iPS细胞技术正在被不断完善，就iPS细胞的研究历程及在诱导iPS细胞上的最新研究进展进行综述。The induced pluripotent stem cells（iPS cells） were regarded as a milestone of life sciences, which originated a relatively easy-to-use and more stable somatic cell nuclear reprogramming method, having a potential value in basic research of biology and clinical application. However, its applications were limited by high carcinogenic rate and low efficiency of reprogramming. Currently, iPS cell technology is being continuously improved. This article reviewed the history and the latest research progress in iPS cells.

关 键 词：诱导多功能干细胞 重编程 干细胞因子 基因转染 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]