烧伤脓毒症患者血清Wnt5a水平变化及其临床意义  

Study on Changes of Wnt5a Levels in Burn Patients with Sepsis

作　　者：尹朝奇[1] 贺全勇[1] 罗成群[1] 周建大[1] 朱颉[1] 李萍[1] 陈铁夫[1] 彭浩[1] 徐阳成[1] 陈佳[1] 

机构地区：[1]中南大学湘雅三医院烧伤整形科,湖南省长沙市410013

出　　处：《中国全科医学》2010年第11期1165-1167,共3页Chinese General Practice

基　　金：国家自然科学基金(30672035)

摘　　要：目的观察烧伤脓毒症患者血清Wnt5a水平变化。方法采集烧伤脓毒症患者的血清标本,采用Western blotting法检测Wnt5a水平,并比较轻、中、重度脓毒症患者血清Wnt5a水平。同期选取轻度烧伤的非脓毒症患者8例作对照。结果烧伤脓毒症患者血清Wnt5a水平高于对照者。动态观察发现,脓毒症痊愈后患者血清Wnt5a水平降低,而随着脓毒症病情恶化血清Wnt5a水平持续升高。结论Wnt5a参与了烧伤患者炎症的发病过程,且检测Wnt5a水平可作为炎症严重程度的诊断指标。Objective To investigation the changes of WntSa levels in burn patients with sepsis. Methods Serum samples were collected from patients with burn sepsis, and serum WntSa levels were compared by Western blotting assay between patients with mild, moderate or severe sepsis. Eight burn patients without sepsis enrolled as control. Results WntSa levels were higher in burn sepsis patients than in control. Serum WntSa levels reduced after sepsis was cured, but continuously elevated with the exacerbation of sepsis. Conclusion WntSa, involved in pathogenesis of inflammation in burn patients, can be used as a diagnostic index of inflammation severity.

关 键 词：WNT5A 烧伤 脓毒症 炎症因子 

分 类 号：R644[医药卫生—外科学]