大鼠减体积肝移植术后早期死亡的原因分析  

Cause of Early Death after Reduced-size Liver Transplantation in Rats

作　　者：刘静[1] 李江[2] 张升宁[1] 李铸[1] 李来帮[1] 廖丽琼[1] 冉江华[1] 李立[1] 

机构地区：[1]昆明医学院附属甘美医院肝胆胰一科,云南省昆明市650011 [2]昆明医学院附属第一医院肝胆外科

出　　处：《中国全科医学》2010年第11期1208-1211,共4页Chinese General Practice

摘　　要：目的探讨大鼠减体积肝移植术后早期死亡的原因。方法选择170对健康SD大鼠，体质量为260～280g，供体为雌性（170只），受体为雄性（170只），供、受体体质量相差10g，一般为供体体质量比受体体质量轻。改良前术式实施70只，改良后术式实施100只。结果成功实施的170只大鼠减体积肝移植模型中，早期（术后12h～术后3d）死亡25只，早期死亡率为14．7％，其中改良前术式死亡18只，改良后术式死亡7只。早期死亡的原因分布为：腹腔出血8只（4．7％），肠梗阻4只（2．4％），气体栓塞3只（1．8％），肝功能不良3只（1．8％），气胸3只（1．8％），肺部感染2只（1．2％），复温过度2只（1．2％）。结论大鼠减体积肝移植术后早期最常见的死亡原因是腹腔出血，其次为肝功能不良、气体栓塞、肠梗阻、气胸、肺部感染和复温过度。Objective To analyze the cause of early death after reduce - size liver transplantationin rats. Methods One hundred seventy healthy SD rats （260 - 280 g body weight） were enrolled The donors were female （n = 170 ）, the receptors male （ n = 170）, the body weight difference between them was 10 g, generally donors lighter than receptors. Seventy received unimproved operation, and 100 received improved. Results Twenty - five of 170 rats having received reduced - size liver transplantation successfully died early （including 18 rats having received unimproved operation, 7 received improved, 12 h -3 d after operation, ）, with an early mortality of 14. 7%. Early death causes were intra - abdominal bleeding （4.7%） , intestinal obstruction （ 2.4% ）, gas embolism （ 1.8% ）, liver dysfunction （ 1.8% ）, pneumothorax （ 1.8% ）, pulmonary infection （ 1.2% ） and excessive rewarming （ 1.2% ）. Conclusion The commonest early death cause of rat reduced - size liver transplantation is intra - abdominal bleeding, followed by liver dysfunction, gas embolism, intestinal obstruction, pneumothorax, pulmonary infection and excessive rewarming.

关 键 词：减体积肝移植 大鼠 死亡原因 

分 类 号：R657.3[医药卫生—外科学]