急性一氧化碳中毒患者血清NO和NOS水平及其临床意义  

The serum NO and NOS levels and its clinical significance of patients with acute carbon monoxide poisoning

作　　者：郭志勇[1] 顾欣[2] 王海合[1] 

机构地区：[1]河南省新乡市第一人民医院神经内科,453000 [2]新乡医学院第二附属医院

出　　处：《中国临床实用医学》2010年第4期40-41,共2页China Clinical Practical Medicine

摘　　要：目的探讨一氧化氮（NO）及一氧化氮合酶（NOS）的水平与急性一氧化碳中毒患者病情的关系，寻找表达急性一氧化碳中毒（ACMP）患者病情变化的理想生物学标志。方法应用比色法（colorimetric method）测定40例ACMP患者血清NO及NOS水平，并与38例正常对照进行比较。结果AC-MP组患者血清NO及NOS水平明显高于正常对照组（P〈0．05）。结论NO—NOS系统水平异常在AC-MP引起的缺血缺氧性疾病发生中起重要作用。Objective Exploring the relationship between the nitric oxide （NO） and nitric oxide synthase （NOS） levels and the patients with acute carbon monoxide poisoning,to find an ideal biological marker which can express the changes in patients with acute carbon monoxide poisoning. Methods Measured the levels of serum NO and NOS between 40 cases of acute carbon monoxide poisoning and 38 normal controls by using colorimetric method. Results The serum NO and NOS levels in patients with acute carbon monoxide poisoning were significantly higher than the normal controls （ P 〈 0. 05 ）. Conclusion The anomaly of NO-NOS system levels played an important role in hypoxic-ischemic diseases which caused by the acute carbon monoxide poisoning.

关 键 词：一氧化碳中毒 一氧化氮 一氧化氮合酶 

分 类 号：R5[医药卫生—内科学]