自发性高血压鼠脑底动脉单胺能神经分布的形态学观察  

MORPHOMETRIC OBSERVATION OF THE MONOAMINERGIC INNERVATION ON CEREBRAL VESSELS IN SPONTANEOUSLY HYPERTENSIVE RATS

作　　者：林雪群[1] 程上穆[2] 石嘉庆[1] 

机构地区：[1]江西医学院解剖学教研室 [2]南昌组织学与胚胎学教研室,南昌330006

出　　处：《神经解剖学杂志》1998年第4期371-374,共4页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金

摘　　要：应用免疫组织化学ABC法，对10只雄性自发性高血压大鼠和10只正常大鼠脑底动脉单胺能神经纤维分布进行了观察、在自发性高血压鼠脑底血管的大脑前动脉、大脑中动脉和基底动脉壁上均可见棕褐色的免疫反应阳性纤维，纤维较粗，弯曲，环行走行，密度较高。与正常鼠同一部位脑底动脉壁的阳性纤维密度比较有明显增加。经统计学检验，P＜0．05，表明高血压鼠和正常鼠脑底动脉之间的单胺能神经纤维的密度有明显差异。本文结果提示，高血压鼠脑底动脉各主要分支较正常鼠脑底动脉各主要分支有更高密度的单胺能神经纤维分布，这些纤维属于交感神经纤维，说明交感神经可能在高血压鼠的脑血管活动和对高血压的发生和发展具有重要的作用。Morphometric structures of the monoaminergic innervation on cerebral arteries in 10 spontaneously hypertensive rats (SHR) and 10 normotensive Wistar-Kyoto rats (WKY), used as control group, was studied with immunoperoxidase ABC technique, employing tyrosine-hydroxylase (TH) as label. The immunopositive fibers with the brown linear structures were observed on the anterior cerebral artery, middle cerebral artery and basilar artery in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. Monoanlinergic nerve fibers were much denser in all cerebral arteries of SHR than those of WKY rats.Student's t-test was used and P<0. 05, indicating significant difference between the density of monoaminergic innervation in cerebral arteries of SHR and those of WKY rats. It suggests that the sympathetic nerves played an important role in the maintenance and development of hypertension in SHR.

关 键 词：单胺能神经 脑底动脉 免疫组织化学 高血压 大鼠 

分 类 号：R544.1[医药卫生—心血管疾病] R338[医药卫生—内科学]