咪达唑仑联合芬太尼在COPD患者有创机械通气中的临床应用  

Midazolam combined with fentanyl in patients whith invasive mechanical ventilation in COPD

作　　者：臧泽林[1,2] 雷霆[1,2] 张应宏[1,2] 曹海泉[1,2] 尚娟[1,2] 

机构地区：[1]川北医学院第二临床医学院 [2]南充市中心医院ICU,四川南充637000

出　　处：《西部医学》2010年第4期642-643,共2页Medical Journal of West China

摘　　要：目的观察咪达唑仑联合芬太尼在重症监护病房（ICU）COPD患者有创机械通气中的应用，评价其镇静效果及安全性。方法93例有创机械通气的COPD患者，给予咪达唑仑联合芬太尼持续静脉泵入，定时观察意识状态，人机协调，呼吸动力学指标及动脉血气分析。结果给予咪达唑仑联合芬太尼后，94．6％（88／93）的患者Ramsay评分达2分～4分，用药后患者呼吸动力学指标（PIP、PP、PM、RI、RE、CMP）及SpO2、pH、PCO2、PO2均有明显改善（P〈0．05）。结论咪这唑仑联合芬太尼在COPD患者机械通气时镇静效果好，安全性高，可在临床推广应用。Objective To observe the combined midazolam fentanyl in the intensive care unit （ICU） COPD patients with invasive mechanical ventilation in the application and evaluate its efficacy and safety of sedation. Methods 93 cases of invasive mechanical ventilation in COPD patients were treated with midazolam combined continuous intravenous infusion of fentanyl. The sedative effect, state of consciousness, human-machine coordination, respiratory parameters and arterial blood gas analysis were observed. Results 94.6% （88/93） of patients with Ramsay score of 2 to 4 hours after administration in patients and respiratory parameters （PIP, PP, PM, RI, RE, CMP） and SpO2, pH, PCO2, PO2 were significantly improved with statistical significance （P〈0.05）. Conclusion It is effective and safe to treat patients with COPD with combined midazolam and fentanyl.

关 键 词：咪达唑仑 芬太尼 机械通气 COPD 

分 类 号：R971.3[医药卫生—药品]