2-氯乙胺盐酸盐的合成工艺研究  

Study on Synthesis of 2-Chloro-ethylamine Hydrochloride

作　　者：祝一锋[1,2] 胥洪原[1,2] 王云峰 张华强 石明孝 

机构地区：[1]浙江工业大学化工学院 [2]浙江大学应用化学研究所

出　　处：《精细化工》1998年第2期48-50,共3页Fine Chemicals

摘　　要：以乙醇胺为原料用液相法经成盐酸盐化及氯化两步反应合成２氯乙胺盐酸盐，研究了反应的主要影响因素。成盐反应在室温下，乙醇胺与浓盐酸１∶１条件下中和反应。氯化反应以甲苯为溶剂，乙醇胺盐酸盐与二氯亚砜的摩尔比为１∶１０４，反应温度６６℃，反应时间２５ｈ，获得了最佳反应结果，产品总收率９５８％，纯度９９１％。2-Chloro-ethylamine hydrochloride was synthesized from ethanolamine by hydrochlorination followed by reaction with thionyl chloride.A study of the effects on the synthesis was done,which gave the optimum conditions that hydrochlorination was run at room temperature with 1∶1 molar ratio of ethanolamine to hydrochloride followed by reaction with thionyl chloride at 66℃ for 2.5h with 1∶1.04 molar ratio of ethanolamine hydrochloride to thionyl chloride and with methylbenzene used as solvent.The total yield is 95.8% in 99.1% purity.

关 键 词：氯乙胺盐酸盐 乙醇胺 合成 工艺 

分 类 号：TQ226.33[化学工程—有机化工]