白藜芦醇对裸鼠胃癌移植瘤预防性抑制作用及对免疫调节的影响  

Effect of Preventive Inhibition of Resveratrol on Nude Mice Transplantation Tumor of Stomach Cancer and Its Effect on Immunological Regulation

作　　者：郑国华[1] 吴异兰[1] 陈旭征[2] 郑智慧[1] 

机构地区：[1]福建中医学院护理学系,福建福州350108 [2]福建中医学院中西医结合研究院,福建福州350108

出　　处：《福建中医学院学报》2010年第2期32-35,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省青年人才基金(2006F3059)

摘　　要：目的探讨白藜芦醇对裸鼠胃癌移植癌的预防性抑制作用及对免疫调节的影响。方法用胃癌MGC-803细胞株建立裸鼠胃癌移植瘤模型,通过白藜芦醇预防性给药,观察不同剂量白藜芦醇对裸鼠胃癌移植瘤的生长抑制作用及对T细胞免疫调节影响。结果白藜芦醇中高剂量组能明显抑制裸鼠胃癌移植瘤的生长,抑制率可达到50%(P<0.05),并能有效升高裸鼠外周血T细胞亚群的数量。结论白藜芦醇能有效预防性抑制裸鼠胃癌移植瘤的生长,可能与调节裸鼠T细胞免疫功能有关。Objective To explore the effect of preventive inhibition of resveratrol on nude mice transplantation tumor of stomach cancer and its effect on immunological regulation. Methods The models of nude mice transplantation tumor of stomach cancer were established with the gastric cancer MGC-803 cell line. The growth inhibition effect of resveratrol on nude mice transplantation tumor of stomach cancer and its effect of immunological regulation on T cell were observed after preventive administration of resveratrol. Results The growth of nude mice transplantation tumor of stomach cancer was significantly inhibited in the high-dose group, the inhibition rate reached 50% （P〈0.05）, and the number of T cell subsets in peripheral blood was increased significantly. Conclusion The resveratrol has effect of preventive inhibition on the growth of nude mice transplantation tumor of stomach cancer, which may be related to its regulation effect on immune function of T cell.

关 键 词：白藜芦醇 胃癌移植瘤 预防作用 免疫调节 裸鼠 

分 类 号：R285.5[医药卫生—中药学]