铜绿假单胞菌医院感染分布及耐药性分析  

Distribution and drug-resistance of Pseudomonas aeruginosa in nosocomial infections

作　　者：孙各琴[1] 张秀明[1] 兰海丽[1] 莫姗[1] 朱娇贞[1] 胡婷[1] 

机构地区：[1]中山市人民医院检验中心,广东中山528400

出　　处：《中国病原生物学杂志》2010年第3期200-201,204,共3页Journal of Pathogen Biology

摘　　要：目的探讨铜绿假单胞菌（PAE）医院感染分布及耐药性,为临床医师合理用药提供科学依据。方法采用微量稀释法对临床送检标本分离的PAE菌株进行药敏试验,分析其耐药性。结果1 121株PAE菌株主要分离自重症监护病房（ICU）、呼吸内科、中医康复科和神经内科等住院患者的痰液标本,约占69%。PAE对头孢他啶、哌拉西林/舒巴坦的敏感率为84.2%和82.1%;对氨曲南、庆大霉素、哌拉西哌、头孢吡肟、环丙沙星和左氧氟沙星的敏感率在50%-60%之间,且呈下降趋势;对复方新诺明、氨苄西林/舒巴坦的敏感率仅为3.6%和1.6%。结论铜绿假单胞菌耐药性已十分严重,临床应根据药敏结果合理使用抗生素。Objective To investigate the distribution and drug resistance of Pseudomonas aeruginosa（PAE） in nosocomial infections in order to provide scientific evidence for the rational use of antibiotics.Methods Drug sensitivity testing was performed on PAE isolated from clinical specimens using the broth microdilution test and its drug resistance was examined.Results In total,1 121 strains of PAE were mainly isolated from the intensive care unit（ICU） and departments of respiratory medicine,rehabilitation,and neurology.PAE was mainly isolated from sputum（about 69% of specimens）.Sensitivity testing with 12 types of antibiotics showed that PAE was sensitive to ceftazidime（84.2%） and piperacillin/tazobactam（82.1%）.PAE＇s sensitivity to aztreonam,gentamicin,piperacillin,cefepime,ciprofloxacin,levofloxacin,and imipenem was about 50%-60% and tended to decline.Its sensitivity to trimethoprim/sulfamethoxazole and ampicillin/sulbactam was only 3.6% and 1.6%,respectively.Conclusion PAE drug resistance is very serious.Clinicians should use antibiotics rationally in accordance with the results of drug susceptibility tests.

关 键 词：医院感染 铜绿假单胞菌 分布 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]