参七汤对PCI术后hsCRP、sIL-2R及活化T淋巴细胞的影响  

Effect of Shenqi Decoction on hs-CRP,sIL-2R and Activation of T Lymphocytes after Percutaneous Coronary Intervention

作　　者：王文会[1] 赵华云[1] 郎江明[1] 陈伟强[1] 罗子幸[1] 余秀兰[1] 贺青军[1] 

机构地区：[1]广东省佛山市中医院

出　　处：《中西医结合心脑血管病杂志》2010年第4期413-415,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省中医药管理局课题基金资助项目(No.2060007)

摘　　要：目的观察参七汤对冠状动脉介入(PCI)术后炎症免疫反应、机体免疫状态以及再狭窄的影响,并探讨其作用机制。方法PCI术后患者88例,采用随机、对照方法,分为治疗组(45例)和对照组(43例),随访6个月,观察再狭窄发生率,炎症反应指标:超敏C-反应蛋白(hsCRP),活化的T淋巴细胞:CD3+/HLA-DR+,可溶性白介素2受体(sIL-2R),并结合血瘀证、气虚证计分,评价参七汤对冠心病PCI术后再狭窄的影响和作用机制。结果治疗组再狭窄率少于对照组(P<0.05)。PCI术后,CD3+/HLA-DR+较术前降低,sIL-2R、hsCRP较术前升高,加用参七汤治疗后,CD3+/HLA-DR+水平较对照组升高(P<0.01),sIL-2R、hsCRP水平较对照组降低(P<0.01),血瘀证计分和气虚证计分治疗组亦显著低于对照组(P<0.01),且持续到术后6个月。结论参七汤能有效减少冠心病PCI术后再狭窄的发生。减少支架引起的炎症免疫反应,调节机体免疫状态,是其预防PCI术后再狭窄的机制之一。Objective To observe the effect of Shenqi decoction on inflammation and immune reaction, immune state, restenosis （RS） after percutaneous coronary intervention（PCI）. Methods Eighty - eight patients（pts） after PCI were randomly divided into two groups ： Shenqi decoction group （n = 45） and control group （n = 43）. Following follow - up 6 months, the levels of high sensitive C - reactive protein （hsCRP）, the marker of activation of T lymphocytes CD3＋ /HLA - DR＋ , and soluble interleukin - 2 receptor （sIL - 2R） were ob- served. Based on the scores of blood -stasis syndrome and Qi- deficiency syndrome, the effect of Shenqi decoction on restenosis after PCI and the mechanism of its action were evaluated. Results The incidence of RS in Shenqi decoction group was lower than that in the control group （P〈0.05）. The levels of CD3＋/HLA - DR＋ were decreased after PCI, while the levels of hsCRP and sIL - 2R were in- creased. After treatment, the levels of CD3＋/HLA - DR＋ in Shenqi decoction group was obviously advanced and sIL - 2R and hsCRP were obviously degraded than that in control group（P〈0.01）. The scores of blood- stasis syndrome and of Qi- deficiency syndrome in the treatment group were significantly lower than that in the control group （P〈0.01）, and these remained to 6 months. Conclusion The Shenqi decoction could effectively reduce the occurrence of restenosis after PCI,and it could reduce the inflammation and immune reac- tion of the stents and regulate the immune state to prevent the RS.

关 键 词：参七汤 冠心病 支架内再狭窄 炎症免疫反应 T淋巴细胞 

分 类 号：R541.4[医药卫生—心血管疾病] R259[医药卫生—内科学]