4-溴邻苯二甲酸酯的合成  

Synthesis of di-n-butyl 4-bromophthalate

作　　者：孙树娟[1] 李效军[1] 许文倩[1] 

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《化学试剂》2010年第1期87-90,共4页Chemical Reagents

摘　　要：标题化合物为改性的齐格勒-纳塔催化剂的内给电子体。比目前所应用的邻苯二甲酸酯在维持较高的立构规整度的同时更能提高催化剂活性,在工业生产中具有良好的应用前景。设计了以邻苯二甲酸二甲酯、溴酸钠及正丁醇为主要原料,经溴化和酯交换两步反应制备4-溴邻苯二甲酸二正丁酯的合成方法。以邻苯二甲酸二甲酯计产品的综合收率为84.9%,此方法比文献方法的收率提高了47.5%。同时以反应中间体4-甲基邻苯二甲酸二甲酯为原料合成了4-溴邻苯二甲酸二异丁酯及4-溴邻苯二甲酸二异辛酯,单步收率>90%,实验所得中间体及产品结构经1HNMR分析确定。As internal electron donor in the Ziegler-Natta catalyst,4-bromophthalate could improve the catalytic activities,besides its higher stereoregularity,simliar to that of phthalate,which has very strong potential application in the industry.Di-n-butyl 4-bromophthalate was prepared by using di-metyl phthalate,sodium bromate,n-butyl alcohol as raw materials via bromination and transesterification process.The overall yield of di-metyl phthalate was around 84.9%,which is higher of 47.5% than that by the present literature report.Di-iso-butyl 4-bromophthalate,di（2-ethylhexyl） 4-bromophthalate were synthesized by using intermediate of dimethyl 4-bromophthalate as initial material,whereas the yield was more than 90%.The structure of the intermediate and final product was characterized by 1HNMR method.

关 键 词：邻苯二甲酸二甲酯 溴化反应 酯交换反应 

分 类 号：O625.5[理学—有机化学]