3-碘-1H-吡唑并[3,4-b]吡嗪的合成  

Synthesis of 3-Iodo-1H-pyrazolo[3,4-b] pyrizine

作　　者：匡仁云[1] 郭瑾[1] 周小春[1] 黄春芳[1] 

机构地区：[1]井冈山大学化学化工学院,江西吉安343009

出　　处：《中国医药工业杂志》2010年第4期249-250,共2页Chinese Journal of Pharmaceuticals

摘　　要：2-氰基吡嗪和氯化亚砜在DMF作用下反应得3-氯-2-氰基吡嗪,经水合肼闭环得3-氨基-1H-吡唑并[3,4-b]吡嗪,再经NaNO2/p-TsOH/KI一步完成重氮化-碘代反应得到3-碘-1H-吡唑并[3,4-b]吡嗪,总收率约31%。3-Iodo-1H-pyrazolo[3,4-b]pyrizine was synthesized from 2-cyanopyrazine and thionyl chloride to give 3-chloro-2-cyanopyrazine,which was subjected to cyclization with hydrazine hydrate,followed by diazotization and iodination by NaNO 2 /p-TsOH/KI with an overall yield of about 31%.

关 键 词：3-碘-1H-吡唑并[3 4-b]吡嗪 中间体 合成 

分 类 号：O626.21[理学—有机化学]