光谱法研究CdSe量子点与喹诺酮类药物的相互作用  

Spectroscopic study on the interaction of CdSe quantum dots with quinolones

作　　者：范敬周[1] 周娟[1] 吕诗言[1] 唐金艳[1] 胡艳军[1] 周兴旺[1] 吕鉴泉[1] 

机构地区：[1]湖北师范学院污染物分析与资源化技术湖北省重点实验室,湖北黄石435002

出　　处：《湖北师范学院学报（自然科学版）》2010年第1期62-66,共5页Journal of Hubei Normal University(Natural Science)

基　　金：教育部重点项目(206096);湖北省教育厅创新团队项目和重点项目(D200922005)资助

摘　　要：用荧光光谱法研究了洛美沙星、依诺沙星、左氧氟沙星三种喹诺酮药物与半胱氨酸修饰的CdSe量子点的相互作用,文中分别考察了pH、N-羟基丁二酰亚胺(NHS)用量等对相互作用的影响。结果表明:在NHS存在下,三种药物均能够使CdSe量子点的荧光发生猝灭,猝灭机理为动态猝灭。热力学结果显示,其作用是由疏水作用引起的、自发的、熵驱动过程。The interactions between quinolones（Lomefloxacin,Enoxacin and Levofloxacin） and L-Cysteine stabilized CdSe quantum dots（CdSe QDs） were studied by fluorescence spectroscopy.The effect of pH and the amount of N-hydroxysuccinimide（NHS） on the fluorescence of CdSe QDs were investigated.The results revealed that all of the three quinolones can quench the fluorescence of CdSe QDs with a dynamic mechanism in the presence of NHS.Thermodynamic results demonstrated that the interactions were spontaneous and entropically driven process,in which hydrophobic force play a major role.

关 键 词：CDSE 量子点 喹诺酮 荧光光谱 

分 类 号：O657.3[理学—分析化学]