乳化溶剂扩散法制备吲哒帕胺缓释微球  

Preparation of indapamide sustained-release microspheres by emulsion-solvent diffusion

作　　者：范博[1] 阎志飞[1] 丁红[1] 罗斌华[1] 杜艳[1] 

机构地区：[1]山西医科大学药学院药剂教研室,太原030001

出　　处：《中国药物与临床》2010年第4期373-374,共2页Chinese Remedies & Clinics

基　　金：山西省自然科学基金(2008011077-3)

摘　　要：目的制备吲哒帕胺缓释微球。方法以乙基纤维素和水溶性高分子材料聚乙二醇6000为载体,采用乳化溶剂扩散法制备吲哒帕胺缓释微球,通过正交设计试验优选了处方和制备工艺,并对所制微球的形态、粒径分布、载药量和包封率等进行了考察。结果该法所制微球外观圆整、流动性好,粒度分布在80～200μm范围内的微球占总数的84.5%,载药量为36.8%,包封率为78.1%。结论该法可用于吲哒帕胺缓释微球的制备。Objective To prepare indapamide sustained-release microspheres. Methods The emulsion-solvent diffusion method was used to prepare indapamide sustained-release microspheres with Ethyl cellulose and Macrogol 6000, with orthogonal test design determining the optimal recipe and procedure. The conformation, particle size distri- bution, drug loading and incorporation efficiency were investigated. Results The microspheres were spherical and smooth in appearance. The recovery of microspheres （80-200 um） was more than 84.5%. The drug loading was 36.8% and incorporation efficiency reached 78.1%. Conclusion The presented method was suitable for preparing indapamide sustained-release microspheres.

关 键 词：迟效制剂 正交试验 乳化溶剂扩散法 

分 类 号：R943[医药卫生—药剂学]