腺苷脱氨酶在结核性浆膜腔积液中诊断价值的循证评价  

Value of Adenosine Deaminase (ADA) for the Diagnosis of Tuberculous Serous Cavity Fluidify:Evidence-based Evaluation

作　　者：李姣[1] 朱渝[1] 屈艺[1] 母得志[1] 

机构地区：[1]四川大学华西第二医院儿科,成都610041

出　　处：《中国循证医学杂志》2010年第4期495-498,共4页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(项目编号:30973326)

摘　　要：目的探讨腺苷脱氨酶(adenosine deaminaseADA)检测在结核性浆膜腔积液中的诊断价值。方法检索PubMed和CNKI数据库,查阅关于ADA在各种结核性浆膜腔积液诊断中应用的相关文献并进行评价。结果国内外有多个RCT和Meta分析评价了对结核性浆膜腔积液中ADA活性水平的诊断价值,现有证据表明ADA活性水平测定在各种肺外结核中的诊断敏感性和特异性都很高,各种肺外结核渗出液中ADA活性水平的最佳阈值为40IU/L左右。结论检测结核性浆膜腔积液患者渗出液中ADA活性水平是一个快速、方便、安全有效的结核辅助诊断方法。Objective To investigate the value of adenosine deaminase （ADA） for the diagnosis of tuberculous serous cavity fluidify. Methods The literatures on the application of ADA for the diagnosis of tuberculous serous cavity fluidify in the database including PUBMED and CNKI were reviewed. Results Studies including randomized controlled trial or meta-analysis have performed to determine the level of ADA in the effusion of tuberculous serous cavity fluidify. These studies have sufficiently proved that ADA is a specific and sensitive method for the diagnosis of extrapulmonary tuberculosis. Most of the studies have determined the optimal cut-off value of ADA in the effusion of tuberculous serous cavity fluidify. Conclusion Measurement of ADA in the effusion of tuberculous serous cavity fluidify is widely used as a fast, convenient, safe and effective adjunctive diagnostic method of tubeculosis in clinic.

关 键 词：结核性浆膜腔积液 腺苷脱氨酶 诊断价值 系统评价 

分 类 号：R446.1[医药卫生—诊断学]