纤维堆囊菌Soce90菌株发酵合成新型抗癌物质epothilones的营养控制  

Nutritional control of epothilones porduction by Sorangium cellulosum strain So ce 90

作　　者：李越中[1] 

机构地区：[1]德国国家生物技术研究中心(GBF)天然产物学部

出　　处：《中国抗生素杂志》1998年第6期420-424,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金

摘　　要：Ｅｐｏｔｈｉｌｏｎｅｓ是从粘细菌纤维堆囊菌（Ｓｏｒａｎｇｉｕｍｃｅｌｕｌｏｓｕｍ）中新分离的一类具有抗肿瘤活性的次级代谢产物。本文研究了影响纤维堆囊菌Ｓｏｃｅ９０菌株合成ｅｐｏｔｈｉｌｏｎｅｓ的条件。结果表明：菌体的生长状态对产物的合成有影响，指数期接种物、低氮高碳培养条件、某些盐离子、氨基酸和乙酸盐对ｅｐｏｔｈｉｌｏｎｅｓ的合成有益。Epothilones were novel bioactive secondary metabolites, which were newly isolated from Sorangium cellulosum . This paper studied the conditions that influenced the production of epothilones by strain So ce 90. The results showed that the cell growth conditions affected the production. Exponential inoculum, low nitrogen and high carbon media, some inorganic salts, amino acids and acetate were essential for biosynthesis of epothilones. Thus, a condition of higher and steady production of epothilones was obtained.

关 键 词：纤维堆囊菌 EPOTHILONES 发酵 合成 抗癌药 

分 类 号：R979.14[医药卫生—药品] TQ465.92[医药卫生—药学]