血清总胆汁酸、胆固醇、AST/ALT比值与肝硬化Child-Pugh分级的关系  

Relationships of serum total bile acids,cholesterol and AST/ALT ratio with the Child-Pugh classification in cirrhosis

作　　者：齐晓丹[1] 沙子健[2] 李兆岩[3] 于海涛[4] 

机构地区：[1]齐齐哈尔医学院生化教研室,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院药学实验中心,黑龙江齐齐哈尔161006 [3]齐齐哈尔医学院第一附属医院检验科,黑龙江齐齐哈尔161041 [4]齐齐哈尔医学院生物遗传教研室,黑龙江齐齐哈尔161006

出　　处：《中国医药导报》2010年第11期13-14,17,共3页China Medical Herald

基　　金：黑龙江省青年科学基金项目(QC2009C89)

摘　　要：目的:探讨肝炎后肝硬化患者不同Child-Pugh分级与血清总胆汁酸(TBA)、胆固醇(CHO)、AST/ALT比值的相互关系。方法:选取临床诊断为肝炎后肝硬化患者76例,按Child-Pugh评分进行分级(A、B、C级);对照组48例为健康体检者,并检测血清TBA、CHO、AST/ALT比值。结果:肝硬化组与对照组比较,血清TBA升高,血清CHO降低,AST/ALT比值升高,差异有高度统计学意义(P<0.01)。肝硬化患者Child-Pugh分级A、B、C级之间比较,差异有高度统计学意义(P<0.01)。结论:肝硬化患者血清TBA、CHO、AST/ALT比值联合检测有助于肝硬化患者进行肝功能分级,并有助于评估肝功能受损程度。Objective：To study the possible relationships of serum total bile acids （TBA）,cholesterol （CHO） and AST/ALT ratio to different Child-Pugh classifications in patients with HBV-related cirrhosis. Methods：Selected clinically diagnosed 76 cases of patients with liver cirrhosis according to Child-Pugh score for classification （grade A,B and C） as the cirrhosis group,48 cases of healthy persons were served as the control group,the serum TBA,CHO and AST/ALT ratio of the two groups were detected. Results：Compared with the control group,the serum TBA of cirrhosis group increased,serum CHO reduced,AST/ALT ratio increased,they showed significant difference （P〈0.01）. Patients with liver cirrhosis according to Child-Pugh classification had significant difference among grade A,B and C （P〈0.01）. Conclusion：Patients with liver cirrhosis with serum TBA,CHO and AST/ALT ratio of the joint detection helps classification of liver function in patients with liver cirrhosis,and helps to assess the degree of liver dysfunction.

关 键 词：肝硬化 CHILD-PUGH分级 总胆汁酸 胆固醇 AST/ALT比值 

分 类 号：R657.31[医药卫生—外科学]