特异性口服免疫耐受诱导的免疫学机制及其临床应用  

Specific Oral Tolerance Induction in Food Allergy

作　　者：郭翔[1] 黄琼[1] 杨杏芬[1] 

机构地区：[1]广东省疾病预防控制中心,广州510080

出　　处：《中华临床免疫和变态反应杂志》2010年第1期50-54,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家质检公益性行业科研专项项目(2007GYJ046);广东省"十一五"医学重点专科(食品安全监测检测)项目

摘　　要：特异性口服免疫诱导(specific oral tolerance induction,SOTI)是一种将曾经使患者发生过敏反应的食物作为抗原,从极低剂量开始给患者口服,以后逐渐缓慢增大剂量,维持一段时间后使患者对此抗原发生免疫耐受的现象。SOTI的发生发展受到多种免疫机制和诸多因素的影响,对SOTI免疫学机制深入细致地研究将为进一步了解食物过敏反应发生的机制,及其治疗和预防发挥积极的作用。Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose, then, the patient will be tolerance to the food. The specific oral tolerance induction （ SOTI） was influenced by many kinds of factors. The study of SOTI will play an important role in the treatment and preventive of food allergy in the future.

关 键 词：经口耐受 特异性口服免疫耐受诱导 食物过敏 

分 类 号：R593[医药卫生—内科学]