Foxp3^+调节性T细胞及其与鼻部炎性疾病的关系  

Foxp3^+ T Regulatory Cells and its Role in Pathogenesis of Nasal Inflammatory Disorders

作　　者：蔡克敏[1,2] 李华斌[1,2] 程雷[1,2,3] 

机构地区：[1]南京医科大学第一附属医院 [2]江苏省人民医院耳鼻咽喉科,南京210029 [3]南京医科大学国际变态反应研究中心,南京210029

出　　处：《中华临床免疫和变态反应杂志》2010年第1期61-69,共9页Chinese Journal of Allergy & Clinical Immunology

基　　金：江苏省"科教兴卫工程"医学重点学科基金(XK200719);江苏省"科教兴卫工程"重点人才基金(RC2007065)

摘　　要：CD4+CD25+调节性T细胞(Tregulatory cells,Treg)能抑制病理性免疫反应,维持自身免疫耐受和免疫平衡。CD4+CD25+Treg主要由两类细胞亚群组成,一类是胸腺来源的自然Treg,另一类是在外周由幼稚T细胞分化而来的诱导性Treg。叉头状转录因子p3是CD4+CD25+Treg的特异性标志,在其发生及功能发挥中起关键作用。同时,CD4+CD25+Treg的扩增和激活也受到细胞因子、共刺激分子等多种分子和信号通路的控制。目前研究认为,变应性鼻炎、慢性鼻窦炎和鼻息肉等鼻部炎性疾病与CD4+CD25+Treg功能障碍密切相关。CD4^＋CD25^＋ T regulatory cells （Treg） actively suppress pathological immune response, contributing to the maintenance of immunological self-tolerance and immune homeostasis. CD4^＋CD25^＋ Treg consists of two main subgroups. One is naturally Treg which developed in the thymus, another is induced Treg differentiated from nave T cells in the periphery. Transcription factor forkhead box p3 （ Foxp3） is a specific marker and crucial transcription factor for the development and functionality of CD4 ＋CD25＋ Treg. Also, the expansion and activation of CD4 ＋CD25 ＋ Treg is controled by various molecules and signaling pathways, such as cytokines and co-stimulatory factors. There is evidence shown that the impairment of CD4 ＋CD25 ＋ Treg play important role in the pathogensis of nasal inflammatory disorders such as allergic rhinitis, chronic rhinosinusitis, and nasal polyps.

关 键 词：调节性T细胞 叉头状转录因子p3 变应性鼻炎 慢性鼻窦炎 鼻息肉 

分 类 号：R765[医药卫生—耳鼻咽喉科]