多囊卵巢综合征患者血清sICAM-1水平变化及意义  

Levels and significance of sICAM-1 in polycystic ovary syndrome

作　　者：黄卡立[1] 蒋凤艳[2] 黎红芳[2] 

机构地区：[1]广西壮族自治区人口和计划生育研究中心,南宁530021 [2]广西医科大学

出　　处：《山东医药》2010年第14期22-24,共3页Shandong Medical Journal

基　　金：广西科学研究与技术开发计划基金资助项目(2006-25)

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者血清可溶性细胞间黏附分子-1(sICAM-1)水平与脂代谢相关性。方法将96例PCOS患者以体重指数(BMI)≥24 kg/m2为肥胖标准,分为肥胖A组(FA组)和非肥胖A组(NA组);以腰臀比(WHR)≥0.8为肥胖标准,分为肥胖B组(FB组)和非肥胖B组(NB组)。分别测定血清sICAM-1、TG、TC、HDL-C、LDL-C、Apo A1、Apo B、Lp-a水平。采用多元线性回归Enter法分析sICAM-1与脂代谢的相关性。结果FA、FB组血清sICAM-1均水平高于NA、NB组(P均<0.05),FA组TG明显高于NA组(P<0.05),FB组TC、LDL-C明显高于NB组(P<0.05);血清sICAM-1水平与TC、LDL-C水平呈正相关(r=0.945,P<0.05)。结论PCOS患者血清sICAM-1水平及脂代谢异常与肥胖有密切联系,PCOS患者sICAM-1水平随着LDL-C、TC水平增高而升高;积极治疗和监测PCOS肥胖患者,可以防止和减少其心血管疾病的发生。Objective To research the relevance between soluble intercellular adhesion molecule-1 （slCAM-1） concentration and lipid metabolism in polycystic ovary syndrome（PCOS）. Methods Ninty-six cases of PCOS patients with BMI 〉124 kg/m^2 by obesity criteria were divided into obese A group （FA group） and non-obese A group （NA group）. With waist-hip ratio （WHR） 〉10.8 for the obesity criteria, they were divided into obese B group （ FB group） and non-obese B group （NB group）. Its were measured the level of sICAM-1, TG, TC, HDL-C, LDL-C, Apo A1, Apo B, Lp-a of all groups. Enter method using multiple linear regression analysis of sICAM-1 and lipid metabolism in relevance. Results The of sICAM-1 level of FA, FB group were higher than that of the NA, NB group （P 〈 0. 05 ）, TG of FA group was signifi- cantly higher than that of NA group （P 〈 0. 05）, TC, LDL-C of FB group were higher than thta of NB group （ P 〈 0.05 ）. The sICAM-1 level were positively correlated with TC, LDL-C levels （r = 0. 945, P 〈 0. 05 ）. Conclusions The serum sICAM-1 level and lipid metabolic disorders and obesity are closely linked in PCOS patients. The sICAM-1 level of PCOS patients is much higher, corresponding to higher LDL-C and TC levels. Treatment and monitoring should be actively obese PCOS patients, to prevent and reduce the occurrence and development of cardiovascular disease.

关 键 词：多囊卵巢综合征 可溶性细胞间黏附分子-1 脂代谢 肥胖 

分 类 号：R588.63[医药卫生—内分泌] R589.2[医药卫生—内科学]