金属离子化合物抗菌活性的微量热法  

MICROCALORIMETRY ON THE ANTIBACTERIAL ACTIVITY OF METAL ION COMPOUNDS

作　　者：黄在银[1] 屈松生[1] 赵群金[1] 冯英[1] 

机构地区：[1]武汉大学化学系

出　　处：《无机化学学报》1998年第4期490-492,共3页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金;高等学校博士学科点专项基金

摘　　要：用微量热法测定了大肠杆菌在四种金属离子化合物作用下的生长代谢热谱。计算了大肠杆菌在指数生长期的生长速率常数ｋ、传代时间Ｇ、生长抑制率Ｉ和发热量Ｑ等参数；建立了热谱信息参量之间的关系，定量地讨论了金属离子化合物对大肠杆菌生长代谢的抑制，并发现可用Ｐｍａｘ和ｔｒ表征大肠杆菌和生长代谢的化合物的抗菌活性。The effects of metal ions on E coli have been studied by microcalorimetry The results show that different kind of metal ions have different effects on E coli and their metabolic power time curves are different as well as the mechanisms of their actions are also different The sequence of the antibacterial activity metal ion compounds is: Zn(Ac) 2·2H 2O>Co(Ac) 2·4H 2O>Cu(Ac) 2·H 2O>Ni(Ac) 2·4H 2O, and their half inhibitory concentrations also increase with this sequence

关 键 词：金属离子化合物 大肠杆菌 抗菌活性 微量热法 

分 类 号：R978[医药卫生—药品] R965.1[医药卫生—药学]