新活素治疗急性心力衰竭临床观察  

Clinical observation of lyophilized recombinant human brain natriuretic peptide for acute heart failure

作　　者：孙树印[1] 张瑞华[1] 李慧[1] 

机构地区：[1]山东省济宁市第一人民医院,272111

出　　处：《临床合理用药杂志》2010年第6期1-2,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察冻干重组人脑利钠肽(新活素)治疗急性心力衰竭(AHF)的临床疗效。方法100例AHF患者随机分为新活素组与硝酸甘油组各50例,2组均给予常规治疗,新活素组在常规治疗基础上加用新活素,硝酸甘油组加用硝酸甘油,观察2组疗效及肺毛细血管楔嵌压(PCWP)、肺动脉压(PAP)的变化。结果新活素组总有效率为96%高于对照组的64%,差异有统计学意义(P<0.05)。新活素组给药后第1、3、6小时的PCWP、PAP降低值高于硝酸甘油组,差异均有统计学意义(P<0.05)。结论新活素治疗AHF临床疗效确切,值得临床推广应用。Objective To study the effficacy of lyophilized recombinant human brain natriuretic peptide（rh-BNP）for treating acute heart failure.Methods 100 patients with acute heart failure were randomly divided into rh-BNP group（n=50）and nitroglycerin group（n=50）.The two groups were given conventional treatment,the rh-BNP group on the basis of conventional therapy with rh-BNP added.Observed the efficacy of two group pressure and pulmonary capillary wedge（PCWP）,pulmonary artery pressure（PAP）changed.Results The total effective rate of rh-BNP group was 96%,higher than 64% of the nitroglycerin group,the difference was statistically significant（P0.05）.The rh-BNP group 1,3,6 hours after administration of PCWP,PAP reduced were lower than nitroglycerin group,the differences were statistically significant（P0.05）.ConclusionThe rh-BNP of the clinical efficacy of treatment of AHF is accurate,and worthy of clinical application.

关 键 词：新活素 硝酸甘油 急性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]