Ge-132稀土配合物及其对单核苷酸磷酯键的催化水解作用  

Rare Earth Complexes with Ge 132 and Their Catalytic Hydrolysis to Phosphatide Bond of Mononucleotide

作　　者：王志强[1] 陈继[1] 朱兵[1] 张树功[1] 

机构地区：[1]中国科学院长春应用化学研究所稀土化学与物理开放实验室

出　　处：《高等学校化学学报》1998年第12期1915-1917,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学重大基金

摘　　要：Ｇｅ－１３２是具有广泛生物活性的一元羧酸有机锗倍半氧化物的低聚物，分子中存在类似冠醚的Ｇｅ－Ｏ－Ｇｅ大环结构．因此，有人认为Ｇｅ－１３２的生物活性可能与这种大环结构与体内金属离子形成配合物有关［１］，但尚无直接的实验证据．因此，合成Ｇｅ－１３２稀土配...The complexes of a series of rare earths with Ge 132 have been prepared. The carboxyl anions of Ge 132 molecule were coordinated to rare earth ion with chelate style. In the complexes molecule, the GeO 3/2 group of Ge 132 were hydrolyzed to become Ge(OH) 3 group, and later does not coordinate with rare earth ions. All of the complexes possess similar properties. In aqueous solution of pH 6 and 50 ℃, these complexes can obviously selectively catalytically hydrolize the phosphatide bond of 5 AMP and 5 dAMP into phosphatic acid and riboside.

关 键 词：稀土配合物 锗132 水解 有机锗 核苷酸 磷酯键 

分 类 号：O627.42[理学—有机化学] Q524[理学—化学]