Gd(DTPA-BIN)与人血清白蛋白作用的核磁共振研究  

NMR Studies of Gd(DTPA BIN) in Human Serum Albumin Solution

作　　者：李欣宇[1] 张善荣[1] 景凤英[1] 吴亦洁[1] 裴奉奎[1] 

机构地区：[1]中国科学院长春应用化学研究所应用谱学开放实验室

出　　处：《高等学校化学学报》1998年第12期2026-2028,共3页Chemical Journal of Chinese Universities

基　　金：中国科学院"九五"预研基金

摘　　要：造影剂通常为Ｇｄ３＋、Ｍｎ２＋或Ｆｅ３＋的稳定化合物．它们能改变体内水分子氢核的弛豫速率，从而提高正常与病变组织的磁共振成像（ＭａｇｎｅｔｉｃＲｅｓｏｎａｎｃｅＩｍａｇｉｎｇ，ＭＲＩ）对比度或显示体内器官的功能状态．因此，开发新优ＭＲＩ造影剂具有重要...Stable gadolinium complexes, such as Gd(DTPA) and Gd(DOTA), are usually used as the contrast agents for magnetic resonance imaging(MRI). Reported here are the enhanced relaxation properties of a novel gadolinium complex, diethylene triaminopentaacetate bis(isoniazid) Gd(DTPA BIN) , in aqueous and in human serum albumin(HSA) solution, which indicates that (1) two Gd(DTPA BIN) can integrate non covalently with one HSA with an equilibrium constant of 0.02 mmol -2 \5L 2; (2) the relaxivities are 3.28 and 4.92 mmol -1 \5L\5s -1 for the free Gd(DTPA BIN) and the Gd(DTPA BIN) 2 HSA conjugator, respectively; (3) the rotational correlation time of protein conjugator is notably higher than that of the free complex. The above results may imply that Gd(DTPA BIN) has a higher tissue selectivity than that of its parent Gd(DTPA).

关 键 词：人血清白蛋白 磁共振成像 造影剂 钆配合物 

分 类 号：R981.9[医药卫生—药品]