超声实时组织弹性成像技术定量评价甲状腺肿块的应用价值  

The value of quantitative analysis in thyroid nodules by real-time tissue elasticity imaging

作　　者：李蔚[1] 项飞翔[1] 李玲[1] 严天慰[1] 张艳容[1] 谢明星[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院超声影像科湖北省分子影像重点实验室,武汉430022

出　　处：《中华超声影像学杂志》2010年第3期219-222,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨超声实时组织弹性成像技术定量评价甲状腺良恶性肿块的应用价值。方法对73例甲状腺肿块患者共95个病灶，应用实时组织弹性成像技术获得肿块应变率与胸锁乳突肌弹性应变率比值，判断病灶的良恶性，并与术后病理结果进行对照，绘制ROC曲线图，获得区分甲状腺肿块良恶性应变率比值的临界值。结果①甲状腺肿块良性组弹性应变率比值为2．06±1．01，恶性组弹性应变率比值为5．05±2．23，两组间差异有统计学意义（P〈O．05）。②甲状腺良恶性肿块弹性应变率比值的ROC曲线下面积为0．929，差异有统计学意义（P〈0．05）。③通过ROC曲线确定良、恶性肿块弹性应率比值的临界点为3．17，其灵敏度、特异度、阳性预测值、阴性预测值分别为96．7％、90．8％、93．3％和96．9％。结论超声实时组织弹性成像技术可以简便、无创、定量地对甲状腺良、恶性肿块进行鉴别诊断。Objective To evaluate the value of the real-time tissue elasticity imaging quantitative method in differential diagnosis of thyroid nodules. Methods Seventy-three patients with thyroid nodules, including 95 lesions,were included in the study. A total of thyroid nodules were examined with traditional ultrasonography and elastosonography from which the strain ratios （SR） were derived, with pathologic results as the reference standard. And a receiver operating characterisitc（ROC） curve was used to identify the value of optimal operating point for differential diagnosis of thyroid nodules. Results （1）The strain ratio of the benign lesions was 2.06± 1.01 ,which was significantly different from the value of malignant lesions 5.05± 2.23（ P 〈0.05）. （2） The area under the curve was 0. 929,which showed a high statistical significance. （3） It showed that the optimal operating point of ROC curve was 3. 17, with high sensitivity （96.7%）, specificity （90. 8% ）, postive predictive value （93.3 %） and negative predictive value （96.9 %）. Conclusions The real-time tissue elasticity imaging can provide a quantitative, noninvasive and convenient tool for evaluating the thyroid nodules.

关 键 词：超声检查 甲状腺肿瘤 ROC曲线 弹性成像 

分 类 号：R445.1[医药卫生—影像医学与核医学] R581.3[医药卫生—诊断学]