177例艾滋病病毒感染者中医证候分析  

Analysis on the Traditional Chinese Medicine Syndromes of 177 HIV/AIDS P atients

作　　者：张苗苗[1] 符林春[1] 孙世辉[2] 

机构地区：[1]广州中医药大学热带医学研究所艾滋病研究室,广东省广州市机场路12号510405 [2]广州市第八人民医院

出　　处：《中医杂志》2010年第4期352-355,共4页Journal of Traditional Chinese Medicine

基　　金：国家"十一五"科技重大专项资助项目(2008ZX10005-005)

摘　　要：目的探讨艾滋病病毒感染者(HIV/AIDS)中医证候的分布和演变规律。方法采用临床流行病学调研方法对177例HIV/AIDS患者进行问卷调查,按照中医临床症状体征观察表收集患者的四诊信息和中医证型资料,并检测CD4+T淋巴细胞计数。结果广东地区青壮年群体受威胁最大,女性感染率上升,性别与感染途径之间相关性很强。患者主症以乏力、咳嗽、纳差为多见,次症以盗汗、皮肤瘙痒、头痛、脱发为多见,体征以皮疹为多见。证型以气阴两虚肺肾不足证型最多。症状体征、证型、各项检查指标在性别、年龄、感染途径上的分布有统计学差异(P<0.01)。CD4与CD8、CD4/CD8比值(Th/Ts)、白细胞(WBC)、淋巴细胞绝对值(LYM)、血红蛋白(HGB)含量相关性很强,对CD4影响最大的是Th/Ts、LYM。结论广东地区HIV/AIDS患者症状体征、证型、各项检测指标在性别、年龄、感染途径的分布有显著差异,提示分类治疗可能对提高疗效有帮助,评价CD4的波动时可参考Th/Ts、LYM这两个指标。Objective To study the rule of distribution and evolvement of TCM syndromes in HIV/AIDS patients. Methods Totally 177 HIV/AIDS patients were investigated with questionnaire in the epidemiologieal study to collect the data of diagnosis, and the routine test of CD4^＋T lymphocyte count was carried out. Results The young and middle-aged females were the most involved group with an increasing incidence in Guangdong Province and with a strong relation of sex and infection route. The main symptoms of the 177 HIV/AIDS patients were fatigue, cough and loss of appetite, the secondary ones were night sweating, skin itching, headache, and hair loss, and the most common sign was skin rash. The leading TCM syndromes were qi and yin deficiency and lung and kidney deficiency. The distribution of symptoms and signs, syndromes and various indices was significantly different in gender, age and infection route （P〈0.01）. There showed a strong relation between CD4 and CDS, Th/Ts, WBC, LYM, HGB. The greatest impact on the CD4 was Th/Ts and LYM. Conclusion There was a significant difference in the distribution of symptoms and signs, syndromes and the lab indices in different gender, age and infection route of HIV/AIDS patients in Guangdong province, indicating that the individual treatment may help to improve the effect. The strong relation between CD4 and CD8, Th/Ts, WBC, LYM, and HGB and the greatest impact of Th/Ts and LYM on CD4 suggest that Th/Ts and LYM can be used as the indices in the evaluation of CD4.

关 键 词：人类免疫缺陷病毒(HIV) 获得性免疫缺陷综合征(AIDS) 中医证候 CD4^+T淋巴细胞 

分 类 号：R259[医药卫生—中西医结合]