补肾调经汤对多囊卵巢综合征模型大鼠血清瘦素、胰岛素和睾酮的影响  

Effect of Bushen Tiaojing Decoction on Serum Leptin, Insulin and Tes tosterone of Polycystic Ovary Syndrome Model Rats

作　　者：冯光荣[1] 胡晓华[2] 周艳艳[2] 

机构地区：[1]河南省郑州市妇幼保健院,郑州市金水路41号450053 [2]河南省中医院妇科

出　　处：《中医杂志》2010年第4期356-358,共3页Journal of Traditional Chinese Medicine

基　　金：河南省教育厅自然科学研究计划项目(2008A360014)

摘　　要：目的探讨补肾调经汤改善多囊卵巢综合征(PCOS)排卵状况的作用机制。方法选用80只雌性SD大鼠,建立PCOS大鼠模型,随机分为空白组、模型组、二甲双胍组、补肾调经汤高剂量组、低剂量组,每组10只,其余大鼠剔除。观察各组大鼠血清瘦素、胰岛素和睾酮激素的变化。结果补肾调经汤高剂量组、低剂量组均可以使PCOS大鼠血清瘦素、胰岛素、睾酮降低,补肾调经汤高剂量组与二甲双胍组在降低瘦素、胰岛素和睾酮水平方面作用相近。结论补肾调经汤可能通过对瘦素、胰岛素、睾酮的调节促进PCOS大鼠排卵。Objective To observe the effect and mechanism of Bushen Tiaojing Decoction （Decoction for reinforcing the kidney and regulating the menstruation） on ovulation of polycystic ovary syndrome （PCOS） rats. Methods Eighty female SD rats were made PCOS models and randomized into blank group, model group, metformin group, Bushen Tiaojing Decoction high and low dose groups, with 10 ones in each and the remainders removed. The changes of serum leptin, insulin and testosterone in each group were observed. Results In Bushen Tiaojing Decoction high and low dose groups, serum leptin, insulin and testosterone were all decreased. The effect of Bushen Tiaojing Decoction high dose group was similar with that of metformin group in decreasing leptin, insulin and testosterone. Conclusion Bushen Tiaojing Decoction could improve the ovulation of PCOS rats through regulating leptin, insulin, and testosterone.

关 键 词：多囊卵巢综合征 补肾调经汤 瘦素 胰岛素 睾酮 大鼠 

分 类 号：R271.9[医药卫生—中西医结合]