参附注射液对二尖瓣置换术患者心脏复跳的影响  

Effects of shenfu injection on recovery of heart beat in patients undergoing mitral valve replacement surgery

作　　者：汪芳俊[1] 陈斌[1] 涂发平[1] 杨光[1] 覃焦[1] 贺红侠[1] 

机构地区：[1]川北医学院附属医院麻醉科,四川南充637000

出　　处：《中国实验方剂学杂志》2010年第4期170-173,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察参附注射液对二尖瓣置换术患者心脏复跳的影响。方法:60例行二尖瓣置换手术的患者随机分为参附注射液(S组)组和生理盐水(N组)组,每组30例。S组在开放主动脉前给予参附注射液,N组给予等量生理盐水。记录主动脉开放至心脏复跳的时间、复跳后1 min ST段改变的绝对值及恢复至正常的时间、复跳后心律失常情况;记录前并行循环时间、主动脉阻断时间和后并行循环时间,以及心脏复跳后多巴胺使用情况。结果:S组主动脉开放至心脏复跳的时间较N组明显缩短(P<0.01);S组心脏自主复跳率较N组高,且室颤发生率较低(P<0.05);S组心脏复跳后ST段改变幅度明显较N组小(P<0.01),ST段恢复正常时间较N组显著缩短(P<0.01);两组患者前并行循环时间、主动脉阻断时间比较差异无显著性(P>0.05),N组后并行循环时间较S组延长(P<0.05);S组心脏复跳后1～30 min、30～60 min、60～90 min,以及ICU期间多巴胺使用量均较N组少(P<0.05)。结论:参附注射液可促进二尖瓣置换术患者心脏自动复跳,而且可减少复跳后心律失常的发生。Objective： To study the effects of shenfu injection on recovery of heart beat in patients undergoing mitral valve replacement surgery.Method： Sixty patients undergoing mitral valve replacement were randomly divided into two equal groups： group S（n = 30）and group N（n = 30）.Shenfu injection at a dose of 1 mL / kg was administered in group S and normal saline of 1 mL /kg was administered in group N before the aorta unclamping 60 s.Clinical data including the incidence of spontaneous recovery of heart beat after aorta unclamping and that of ventricular arrhythmia and the changes of ST-segment one minute after the recovery of heart beat were collected.Meanwhile the time of ante-parallel cycle time,aorta clamping,post-parallel cycle time and the dose of dopamine administered after surgery were recorded.Result： The time from aorta unclamping to spontaneous recovery of heart beat was shorter in group S（P 0.01）.The incidence of spontaneous recovery of heart beat was higher,while that of ventricular arrhythmia is lower in group S（P 0.05）.The changes of ST-segment was more mild and the post-parallel cycle time was shorter in group S.The dose of dopamine administered after surgery was fewer in group S（P 0.05）.Conclusion： The administration of Shenfu injection at a dose of 1 mL /kg before the aorta unclamping one minute facilitated the spontaneous recovery of heart beat and reduced the incidence of ventricular arrhythmia in patients undergoing mitral valve replacement surgery.

关 键 词：参附注射液 二尖瓣置换术 心脏复跳 

分 类 号：R285.6[医药卫生—中药学]