CD55、CD59在特发性血小板减少性紫癜发病中的研究  

Study on the role of CD55 and CD59 in the beginning of Idiopathic Thrombocytopenic Purpura Diseases

作　　者：和迎春[1] 宋建新[2] 张群智[1] 

机构地区：[1]云南省大理学院附属医院检验科,云南大理671000 [2]云南省临床检验中心,云南昆明650032

出　　处：《国际检验医学杂志》2010年第3期238-239,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨特发性血小板减少性紫癜(ITP)患者外周血中血小板表面CD55、CD59抗原表达在其发病中的作用。方法应用流式细胞仪检测30例ITP患者及30例健康对照者外周血血小板表面CD55、CD59抗原表达。结果 ITP患者血小板表面CD55、CD59抗原表达率均明显低于健康对照组(P<0.01)。结论血小板膜上CD55、CD59的缺陷在ITP发病中起着重要的作用。Objective To study the effect of CD55 and CD59 expressing on surface of platelets in to the beginning of idiopathic thrombocytopenic purpura（ITP） disease. Methods To detect the expression of CD55 and CD59 on the surface of platelets by flow cytometry. Results The expression rate of CD55 and CD59 on the surface of platelets in ITP group was lower obviously than that of control group（P〈0.01）. Conclusion The low expression of CD55 and CD59 on the surface of platelets play an important role in the beginning of ITP.

关 键 词：血小板 抗原 CD55 抗原 CD59 紫癜 血小板减少性 特发性 

分 类 号：R446.61[医药卫生—诊断学] R554.6[医药卫生—临床医学]