沈阳地区415例慢性乙型肝炎患者血清标志物与肝脏病理关系的研究  

Relationship between Serum Markers and Liver Pathology in Chronic Hepat it is B in Shenyang Area

作　　者：陈阳[1] 徐桂娟[1] 杨晴[1] 韩永辉[1] 

机构地区：[1]沈阳市第六人民医院,辽宁沈阳110006

出　　处：《中国现代医生》2010年第11期5-6,共2页China Modern Doctor

摘　　要：目的探讨沈阳地区慢性乙型肝炎患者血清标志物与肝组织炎症活动度及纤维化程度之间的关系。方法随机选取慢性乙型肝炎患者415例,行肝穿刺病理检查,定量PCR法检测血清HBV-DNA拷贝数,ELISA法测定HBsAg、抗-HBc、HBeAg、抗-HBe。结果 HBeAg阳性率随着HBV-DNA载量的增加显著升高(χ2=63.05,P<0.05),而抗-HBe阳性率随着HBV-DNA载量的增加显著降低(χ2=37.32,P<0.05)。随着肝脏炎症和纤维化程度的加重,血清标志物为HBsAg(+)、HBeAg(+)、抗-HBc(+)模式的患者所占比例显著减少,而为HBsAg(+)、抗-HBe(+)、抗-HBc(+)模式的患者比例显著增加。分别按肝脏炎症或纤维化程度分组,各组之间的血清HBV-DNA含量均无显著差异(P>0.05)。结论沈阳地区慢性乙型肝炎患者乙肝病毒DNA复制与HBeAg的表达具有一致性,血清HBV-DNA含量与肝脏的炎症及纤维化程度均无相关性,提示不同个体患者血清HBV-DNA复制水平与肝脏炎症程度及纤维化程度没有关系。Objective To analyze the relationship between serum markers and liver pathology in chronic hepatitis B in Shenyang area. Methods Four hundred and fifteen cases of chronic hepatitis B in Shenyang area were enrolled in this study. The HBV-DNA level was detected and liver biopsy was performed for the analysis of the pathological features. Results With an increase in the HBV-DNA level,the positive rate of HBeAg was significantly increased （ X 2= 63.05, P〈 0.05 ）, while the anti-HBe was significantly lowered （ X 2= 37.32, P〈 0.05 ）. There was no closely relationship between HBV-DNA load and liver inflammation and fibrosis degree（P〉0.05）. Conclusion The serum HBV- DNA load has a significant correlation with the positive rate of HBeAg and anti-HBe,but no relation to the liver inflammation and fibrosis degree.

关 键 词：慢性乙型肝炎 血清标志物 肝脏病理 

分 类 号：R512.6[医药卫生—内科学]