超声二维斑点追踪成像技术定量评价正常大鼠左心室整体和局部心肌功能  

Two-dimensional speckle tracking imaging quantitative assessment of left ventricular global and regional myocardial function in normal rats

作　　者：付倩[1] 谢明星[1] 王新房[1] 吕清[1] 方凌云[1] 卢晓芳[1] 王静[1] 王淑珍[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院超声影像科,湖北武汉430022

出　　处：《中国医学影像技术》2010年第3期405-409,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨二维超声斑点追踪成像技术(2D-STI)评价正常大鼠左心室整体和局部心肌功能的应用价值。方法20只健康成年雄性Wistar大鼠分别于基础状态和低剂量多巴酚丁胺负荷时接受超声心动图检查,记录左心室乳头肌短轴高帧频图像。测量节段心肌的收缩期峰值径向应变(PRS)、环向应变(PCS)及左心室整体峰值径向应变(GPRS)和环向应变(GPCS),并采用解剖M型测量左心室舒张末期内径和收缩末期内径(LVIDd、LVIDs)、短轴缩短率(FS)、射血分数(EF)。观察负荷实验时各项指标的动态变化,分别分析EF和左心室整体二维应变值(GPRS、GPCS)的相关性。结果基础状态时大鼠左心室乳头肌短轴各节段PRS值差异无统计学意义(P>0.05),各节段PCS值存在不均一性,前间隔和前壁的PCS测值最大,下壁的PCS测值最小(P<0.05)。多巴酚丁胺负荷时,左心室乳头肌短轴GPRS、GPCS、节段心肌的PRS、PCS值和常规超声心动图的FS和EF随多巴酚丁胺剂量增加而增大(P<0.05);多巴酚丁胺剂量为10.0μg/(kg.min)时上述指标与剂量为5.0μg/(kg.min)时差异均无统计学意义(P>0.05)。基础和负荷状态时EF和左心室整体二维应变值(GPRS、GPCS)均有良好的相关性。结论2D-STI技术可无创、简便地评价正常大鼠基础状态和低剂量多巴酚丁胺负荷时左心室整体和局部心肌形变,具有良好的重复性。Objective To investigate the value of two-dimensional speckle tracking imaging（2D-STI） in assessing left ventricular global and regional myocardial function in normal rats.Methods Echocardiography was performed during low-dose dobutamine stress in 20 normal adult male Wistar rats.High frame rate of 2D images were recorded from the left ventricular short-axis views at the papillary muscle level.Peak systolic radial strain（PRS） and circumferential strain（PCS） of each segment,left ventricular global peak systolic radial strain（G PRS） and circumferential strain（G PCS） were measured at EchoPAC work station.Left ventricular internal diameter at diastole（LVIDd）,systole（LVIDs）,fractional shortening（FS） and ejection fraction（EF） were measured with anatomical M-model echocardiography.Dynamic changes of each index during stress experiment were observed.The correlations between EF and left ventricular global two-dimensional strain（G PRS,G PCS） were analyzed respectively.Results PRS was similar in all segments of mid-ventricular in short-axis view（P 0.05） at baseline,while PCS of each segment showed heterogeneity,with the anteroseptal and anterior wall showing the largest value and the inferior wall showing the lowest value（P 0.05）.G PRS,G PCS,PRS and PCS of each segment increased correspondingly when the dobutamine dose increasing,as well as FS and EF,whereas LVIDd and LVIDs decreased.When dobutamine dose was 10.0 μg/（kg·min）,these parameters were not significantly different compared with those of 5.0 μg/（kg·min）（P 0.05）.Conclusion With good reproducibility,2D-STI can noninvasively and easily assess global and regional left ventricular myocardial deformation of normal rats at rest and during low-dose dobutamine stress.

关 键 词：超声心动描记术 心室功能 左 多巴酚丁胺负荷 二维应变 

分 类 号：R540.45[医药卫生—心血管疾病] R332[医药卫生—内科学]