兔颈动脉急性血栓的MRI分子影像学评价  

Molecular MRI evaluation of acute thrombus in carotid artery in rabbits

作　　者：王志红[1] 刘怀军[2] 吴文新[3] 徐英进[2] 宋利宏[2] 田泽君[4] 王藏海[2] 

机构地区：[1]河北医科大学第二医院神经内科,河北石家庄050000 [2]河北医科大学第二医院医学影像科,河北石家庄050000 [3]河北医科大学第二医院病理科,河北石家庄050000 [4]河北医科大学第二医院心内科,河北石家庄050000

出　　处：《中国医学影像技术》2010年第3期414-417,共4页Chinese Journal of Medical Imaging Technology

基　　金：河北省自然基金(c2006000927)

摘　　要：目的评价纤维蛋白靶向结合MRI对比剂(EP-2104R)对兔颈动脉急性血栓的显示能力,并与非对比增强和Gd-DTPA增强MR进行对比。方法用颈动脉外部损伤和阻塞的方法制作5只兔颈动脉内血栓模型,在血栓诱导后急性期(6.0 h)进行对比剂EP-2104R注入前及注入后MR扫描,并与组织病理学对比。结果纤维蛋白靶向对比剂能准确显示血栓,优于非对比增强MRI和Gd-DTPA增强MRI(P<0.001)。Gd-DTPA增强后不能提高发现血栓的能力。结论纤维蛋白靶向对比剂在显示活体内急性血栓方面优于非对比增强和Gd-DTPA增强MRI。Objective To assess the value of a fibrin-targeted contrast agent（EP-2104R） for MR detection of thrombus,and to compare this modality with non-contrast-enhanced（NCE） MRI and Gd-DTPA injection at acute period after thrombus generation.Methods Thrombus was induced with external injury and stasis in 5 rabbits.MRI was performed before and after contrast agent injection at 6.0 h after injury,and the MRI findings were compared with that of histopathologically examinations.Results EP-2104R enhanced MRI accurately detected thrombus,which was superior to both NCE and Gd-DTPA injection（P 0.001）.Gd-DTPA injection was not associated with improvement of thrombus detection.Conclusion Being a fibrin-targeted MR contrast agent for in vivo detection of acute thrombus,EP-2104R is superior to NCE MRI and Gd-DTPA injection.

关 键 词：兔 颈动脉 血栓形成 磁共振成像 分子影像学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R332[医药卫生—诊断学]