对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效  

Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging

作　　者：牛洪涛[1] 张文丽[1] 郭启勇[2] 于兵[2] 马丽[3] 

机构地区：[1]秦皇岛市第一医院CT室,河北秦皇岛066000 [2]中国医科大学附属盛京医院放射科,辽宁沈阳110004 [3]中国医科大学附属盛京医院感染科,辽宁沈阳110004

出　　处：《中国医学影像技术》2010年第3期425-428,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨对比剂稳态磁化率MR成像技术评估大鼠C6胶质瘤抗血管生成治疗疗效的价值。方法17只荷瘤大鼠随机分成治疗组(n=8)和对照组(n=9)。治疗组腹腔注射人重组内皮抑素(10 mg/kg),对照组腹腔注射相同剂量的生理盐水,共7天。治疗前、后分别行MR检查,测量肿瘤周边区、肿瘤中央区及对侧相应正常脑实质区的血容量(BV)和血管管径指数(VSIMRI)值,并与病理结果相对照。结果治疗后治疗组与对照组肿瘤体积差异有统计学意义(t=5.26,P<0.05)。治疗后肿瘤中心区及周边区BV和VSIMRI值均有下降,以肿瘤周边区下降更为明显(t=4.14、3.66,P均<0.01)。结论对比剂稳态磁化率MR成像技术评估人重组内皮抑素治疗鼠C6脑胶质瘤具有可行性,能够准确反映治疗前后肿瘤BV和VSI的变化。Objective To explore the of value steady-state susceptibility contrast-enhanced MRI（SSCE-MRI） in assessment of anti-angiogenesis therapy in rat C6 glioma.Methods Seventeen rats with the bearing-tumor were randomly divided into the therapy group（n =8） and the contrast group（n =9）.Human-recombination endostatin（10 mg/kg） was injected to animals in therapy group,and saline of the same dose was injected to the contrast group for 7 days.Blood volume（BV） and vessel size index（VSI） were measured of tumors in peripheral,central and normal areas with MR pre-and post-therapy.Results After therapy of endostatin,the tumor volume was obviously different between therapy group and contrast group（t =5.26,P 0.05）.BV and VSI MRI of tumor decreased in both peripheral and central areas,particularly in the peripheral area（t =4.14,3.66,all P 0.01）.Conclusion Assessment of therapeutic effect of anti-angiogenesis in C6 glioma is feasible with SSCE-MRI,and it can reflect the changes of BV and VSI MRI pre-and post-therapy.

关 键 词：胶质瘤 内皮抑素 磁共振成像 血管生成 

分 类 号：R332[医药卫生—人体生理学] R445.2[医药卫生—基础医学]