岛叶的任务态和静息态功能磁共振成像  

Functional MRI study of insula in the task-state and resting-state

作　　者：伊慧明[1] 周媛[2] 张权[1] 张翀[1] 何雅娜[1] 陈静[1] 蒋田仔[2] 张云亭[1] 

机构地区：[1]天津医科大学总医院放射科,天津300052 [2]中国科学院自动化研究所模式识别国家重点实验室,北京100190

出　　处：《中国医学影像技术》2010年第3期439-443,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(30700193);中国科学院自动化研究所模式识别国家重点实验室开放课题(2009-5-1)

摘　　要：目的采用功能磁共振成像(f MRI)研究岛叶在执行词语联想任务时的激活状态,分析岛叶不同部位在语言功能中的作用。方法对28名(男15名,女13名)健康被试者行f MRI研究,试验内容为组块设计的词语联想任务和静息态扫描。采用SPM5和REST1.3软件进行数据处理和统计分析。计算岛叶前部和后部与全脑其他体素之间的功能连接系数,并比较功能连接的差异。结果双侧岛叶前部为正激活脑区,后部为负激活脑区。与左侧岛叶前部有功能连接的区域包括右侧岛叶前部、右侧岛叶后部、辅助运动区(SMA)、左侧颞上回、左侧额中回、左侧额上回、左侧顶下小叶、中扣带回、右侧纹状体和右侧额下回。与左侧岛叶后部有功能连接的区域包括右侧岛叶后部、左侧岛叶前部、右侧颞上回、中扣带回、右侧中央前回及右侧纹状体。与右侧岛叶前部有功能连接的区域包括SMA、左侧额下回、右侧顶下小叶、左侧顶下小叶、左侧颞上回、右侧中央前回、右侧纹状体、中扣带回、左侧额中回、左侧纹状体、右侧额中回、右侧额下回及左侧颞横回。与右侧岛叶后部有功能连接的区域包括右侧中央前回、左侧颞上回、左侧岛叶前部、左侧岛叶后部、右侧缘上回及左侧扣带回。结论岛叶前部与后部的功能连接区域有一定差异,分别以不同方式参与语言任务的完成,左侧岛叶前部在语言功能中的作用可能更为重要。Objective To study the activated status of insula during the performance of word generation task,and to explore the function of different part of insula with functional MRI（fMRI）.Methods Twenty-eight subjects were recruited in this study（male 15,female 13）,all of them underwent block-designed fMRI with word generation tasks and resting-state scan.SPM 5 and REST 1.3 were used to process the data.Bilateral anterior insula and posterior insula were selected as seeds to calculate the connectivity coefficiency with other voxels,and differences between the anterior and the posterior insula were compared.Results Bilateral anterior insula was significantly activated,while bilateral posterior insula was significantly deactivated.The functional connectivity areas with left anterior insula included right anterior insula,right posterior insula,supplementary motor area（SMA）,left superior temporal gyrus,left middle frontal gyrus,left superior frontal gyrus,left inferior parietal lobe,middle cingulate gyrus,right striatum and right inferior frontal gyrus.The functional connectivity areas with left posterior insula included right posterior insula,left anterior insula,right superior temporal gyrus,middle cingulate gyrus,right precentral gyrus and right striatum.The functional connectivity areas with right anterior insula included SMA,left inferior frontal gyrus,right inferior parietal lobe,left inferior parietal lobe,left superior temporal gyrus,right precentral gyrus,right striatum,middle cingulate gyrus,left middle frontal gyrus,left striatum,right middle frontal gyrus,right inferior frontal gyrus and left transverse temporal gyrus.The functional connectivity areas with right posterior insula included right precentral gyrus,left superior temporal gyrus,left anterior insula,left posterior insula,right supramarginal gyrus and middle cingulate gyrus.Conclusion Anterior insula and posterior insula are functionally connected with different areas,and concerned with the language function in different manners.Left lateral a

关 键 词：岛叶 词语联想 正激活 负激活 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学]