海洋胶原肽对四氧嘧啶诱导的糖尿病大鼠肝肾功能的保护作用  

Protective effect of marine collagen peptide on liver and renal injuries in diabetic rats induced by alloxan

作　　者：赵明[1] 张召峰[1] 梁江[1] 李勇[1] 

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,北京100191

出　　处：《卫生研究》2010年第2期147-149,共3页Journal of Hygiene Research

基　　金：国家"十一五"科技支撑计划项目(No.2006BAD28B01)

摘　　要：目的探讨海洋胶原肽对四氧嘧啶诱导的糖尿病大鼠肝肾功能的影响及其机制。方法清洁级SD大鼠,用四氧嘧啶诱导糖尿病大鼠模型后,灌胃给予海洋胶原肽(0.3575、1.0833、3.25g/kgbw)20天,测定大鼠血清中谷丙转氨酶(ALT)和尿素氮(BUN),检测肝脏中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果1.0833g/kgbw和3.25g/kgbw剂量组可显著降低糖尿病大鼠的BUN,3.25g/kgbw剂量组大鼠肝脏SOD与模型对照组相比,活性显著性升高,1.0833g/kgbw和3.25g/kgbw剂量组与模型对照组相比,MDA含量明显降低。结论海洋胶原肽可通过提高机体抗氧化酶活性,从而改善四氧嘧啶诱导糖尿病大鼠的肝肾功能。Objective To investigate the protective effect of Marine Collagen Peptides （ MCPs） on liver and renal injury in diabetic rat induced by alloxan. Methods Twenty-four diabetic rats were randomly divided into four groups and MCPs （0,0. 3575g /kg bw,1. 0833g /kg bw and 3. 25g /kg bw respectively） were given intragastrically. Liver function （ALT） and renal function （BUN） were measured before and 20 days after intervention with Marine Collagen Peptides. The SOD activity and MDA content of liver were measured 20 days after the intervention. Results There were no significant changes of ALT before and after intervention. Treatment of diabetic rats with 1. 0833g /kg bw and 3. 25g /kg bw MCPs resulted in a significant reduction in BUN. The activity of SOD was enhanced and the MDA content was decreased concomitantly in the liver of diabetic rats treated with high MCPs （3. 25g/kg bw）. Conclusion Marine Collagen Peptides might play a protective role on liver and renal function of alloxan-induced diabetic rats by improving antioxidant activity of the body.

关 键 词：海洋胶原肽 四氧嘧啶 肝肾功能 抗氧化 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] Q593.1[医药卫生—内科学]