ICU医院感染革兰阳性菌流行病学调查及耐药性分析  

EPIDEMIOLOGICAL INVESTIGATION AND ANTIBI OTIC RESISTANCE ANALYSIS OF GRAM-POSITIVE COCCI FOR NOSOCOMIAL INFECTIONS IN ICU

作　　者：邵俊[1] 郑瑞强[1] 林华[1] 卢年芳[1] 陈齐红[1] 於江泉[1] 

机构地区：[1]江苏省苏北人民医院&扬州大学临床医学院重症医学科,扬州225001

出　　处：《现代预防医学》2010年第8期1415-1416,1419,共3页Modern Preventive Medicine

基　　金：江苏省"333高层次人才培养工程"基金资助(2007-58)

摘　　要：[目的]了解重症监护病房(ICU)医院感染中革兰阳性(G+)菌流行病学分布及对抗菌药物的耐药性。[方法]对2008年1～12月本院ICU分离的G+菌及其耐药性进行回顾性分析。[结果]共分离出G+菌126株,其中高达47.6%来源于呼吸道,其次是血液占31.7%。G+菌感染以耐甲氧西林金黄色葡萄球菌(MRSA)为主(42.9%),耐甲氧西林表皮葡萄球菌(MRSE)占15.8%。G+菌对利奈唑胺和万古霉素最敏感。[结论]ICU医院感染中G+菌以耐甲氧西林葡萄球菌为主,G+菌对万古霉素和利奈唑胺的敏感率最高。加强医院感染G+菌流行病学调查及耐药性分析,对控制医院感染十分重要。[Objective] To study the epidemiological investigation and antibiotic resistance analysis of Gram-positive （G＋） strains for nosocomial infections in intensive care unit （ICU）. [Methods] Retrospective analysis was made to distribution of G＋ strains and drug resistance situation of ICU in our hospital from Jan. 2008 to Dec. 2008. [Results] A total of 126 G＋ strains were isolated. There were 47.6% of them come from Respiratory tract infection,and 31.7% of them come from blood in-fection. The most frequent isolate of G＋ strains was methicillin-resistant Staphylococcus aureus （MRSA,42.9%）,follow by methicillin-resistant Staphylococcus epidermidis （MRSE,15.8%）. G＋ strains were most susceptible to vancomycin and linezolid. [Conclusion] Methicillin-resistant Staphylococcus is the major pathogenic baciteria of G ＋ strains in nosocomial infections in ICU. G＋ strains were most susceptible to vancomycin and linezolid. Epidemiological investigation and antibiotic resistance analysis of G＋ strains for nosocomial infections are important to control infection in ICU effectively.

关 键 词：重症监护病房 革兰阳性菌 流行病学 耐药性 

分 类 号：R181.22[医药卫生—流行病学]