1412名免费乙肝疫苗接种幼儿免疫效果观察及相关分析  

OBSERVATION AND ANALYSIS ON THE 1 412 FREE HEPATITIS B VACCINATION IN EARLY CHILDHOOD IMMUNIZATION

作　　者：张爱平[1] 蒲秀君 肖刚[1] 

机构地区：[1]怀化市妇幼保健院,怀化418000 [2]怀化市中方县疾病预防控制中心

出　　处：《现代预防医学》2010年第8期1449-1450,共2页Modern Preventive Medicine

摘　　要：[目的]调查和分析乙肝疫苗的免疫效果。[方法]乙肝抗原、抗体的定量测定。[结果]有85.98%的儿童产生了免疫应答,高应答率为43.34%,无应答率为13.67%,抗体浓度呈逐年下降趋势,且以1.5岁后明显,与1岁前比差异有统计学意义。两性之间对比,无论从应答率还是抗体浓度均无统计学差异。[结论]免费乙肝疫苗的接种是安全有效的。探讨是否可通过加大疫苗剂量或改变疫苗佐剂来提高高应答率而减少免疫失败。建议临床工作者在儿童完成乙肝疫苗后定期进行抗体浓度测定。[Objective] To survey and analyze the immunization results of free hepatitis B vaccine. [Methods] We performed quantitative analysis for hepatitis B antigen and antibodies. [Results] 85.98% of children had immune responses,and the high response rate was 43.34%. The non-response rate was 13.67% ,The concentration of antibodies showed a downward trend year by year,and it was more significant for children older than 1.5 years old,and there was significant different between the concentration of antibodies of 1.5 years old and 1 years old children. The response rate and concentration of antibodies did not show significant difference between different sexes. [Conclusion] Free hepatitis B vaccine is safe and effective. We should explore to increase the high response rate and to reduce the immune failure by increasing the dosage of vaccine or changing the vaccine adjuvant. It is suggestion for clinic workers to perform regular antibody concentration determination after finishing incubating the hepatitis B vaccine for children.

关 键 词：免费乙肝疫苗 抗体浓度 免疫应答 

分 类 号：R186[医药卫生—流行病学]