应用遥测系统观察复方丹参片对犬急性心肌缺血的保护作用  

Experimental Study on the Protective Effects of Fufang Danshen Tablets on Acute Myocardial Ischemia in Beagle Canine

作　　者：李文宏[1] 罗晓健[1] 余日跃[1] 张国松[1] 王文哲[1] 崔雪娜[1] 

机构地区：[1]江西中医学院,江西南昌330006

出　　处：《时珍国医国药》2010年第4期777-779,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.30760313)

摘　　要：目的观察复方丹参片对急性心肌缺血犬心功能的影响。方法Beagle犬埋置D70-PCTP植入子,静脉注射垂体后叶素制备急性心肌缺血模型,采用遥测生理信号采集系统实时监测清醒动物的ECG、dp/dtmax、dp/dtmin、心率、左室内压等指标,观察复方丹参片对心肌缺血犬心功能指标的改善作用。结果复方丹参片可明显降低心肌缺血急性期T波幅度,提高dp/dtmax、dp/dtmin,并能升高收缩压、减慢心率,表明复方丹参片可改善缺血心肌的缺血状态和舒缩功能,提高缺血心肌的作功效能。结论复方丹参片对犬急性心肌缺血有良好的保护作用。Objective To observe the effects of Fufang Danshen Tablets on myocardial function in acute myocardial ischemia canine. Methods D70 - PCTP implants were embeded in beagle canine, acute myocardial ischemia model was prepared by Isoprotereno intravenous injection. Indexes of myocardial functions, such as dp/dtmax, dp/dtmin, heart rate, left ventricular pressure ect. , were monitored in sober animals at real time by Dataquest ART 4.0 system, improvement of Fufang Danshen tablets on indexes of myocardial functions decreased by myocardial ischemia were observed. Results Decreased dp/dtmax, dp/dtmin and systolic pressure ect. caused by myocardial ischemia were promoted by Fufang Danshen tablets. Conclusion Fufang Danshen Tablets has perfect protective effects on acute myocardial ischemia.

关 键 词：遥测生理信号采集系统 复方丹参片 垂体后叶素 急性心肌缺血 心功能 

分 类 号：R285.5[医药卫生—中药学]