左旋聚乳酸颈椎可吸收固定板的力学性能测试  

Mechanical property test for poly-L-lactic acid cervical absorbable fixing plate

作　　者：郑伟东[1] 李亮[1] 章培标 李光淳[1] 赵栓柱[1] 

机构地区：[1]吉林省人民医院脊柱外科,吉林省长春市130021 [2]长春应用化学研究所,吉林省长春市130021

出　　处：《中国组织工程研究与临床康复》2010年第12期2191-2194,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：吉林省科技发展计划项目(20060414-3);课题名称:颈椎可吸收固定板的研制与临床应用~~

摘　　要：背景：课题组已成功利用左旋聚乳酸的有限固定强度和可吸收的特性制成了新型颈椎可吸收固定板。目的：进行动物体内降解和力学实验,以测定新型可吸收颈椎左旋聚乳酸固定板的生物力学性能。方法：将长30mm,宽5.5mm,厚度为2.0mm的试样经环氧乙烷消毒后,植入至15只兔的背部肌肉内,分别于术后1,3,5,7个月取出,观察材料的降解变化和机械性能的变化。结果与结论：植入1~5个月,外观观察材料植入体内后未发生明显改变。植入1~7个月材料体积和质量均未发生明显改变。植入1个月冲击强度未发生明显变化,植入3个月略有下降,后又逐渐上升,至7个月时达到甚至超过术前水平。植入后随着时间延长左旋聚乳酸板的弯曲强度呈逐渐下降趋势,但7个月内下降幅度并不显著。术后3~7个月扭转强度略有下降,但并不明显。结果表明,左旋聚乳酸的生物力学强度足够维持骨性融合的全过程,用其制成的颈椎前路固定板可以用于颈椎前路手术的植骨融合固定。BACKGROUND：Previous study has prepared a novel absorbable fixation plates utilizing the limited fixation strength and absorbable characteristics of poly-L-lactic acid（PLLA）.OBJECTIVE：To test the mechanical property of PLLA absorbable fixation plates by in vivo degradation and mechanics experiments.METHODS：Fixation plates with 30 mm length,5.5 mm width,and 2.0 mm thickness were selected.After ethylene oxide sterilization,the plates were implanted to the back muscles of 15 rabbits.At 1,3,5 and 7 months after operation,the plates were removed and the biodegradability and mechanical variation were observed.RESULTS AND CONCLUSION：No significant change appeared in appearance after the materials were implanted in vivo at 1-5 months.There was no obvious change in volume and quality after 1-7 months.Mechanical test results showed that impact strength changed insignificantly after 1 month,followed a slight decrease after 3 months,then increased gradually,which met or exceeded the level before surgery at the end of 7 months.Bending strength decreased gradually over time with insignificant amplitude at 7 months after surgery.Torsional strength decreased insignificantly at 3-7 months after surgery.The results demonstrated that bio-mechanical strength of PLLA is sufficient to maintain the whole process of bony fusion.Anterior cervical fixation plate made of PLLA can be used for anterior cervical fusion and fixation.

关 键 词：左旋聚乳酸 可吸收 固定板 颈椎融合术 生物相容性材料 

分 类 号：R318[医药卫生—生物医学工程]