组织工程化肌腱应用于肌腱运动损伤的修复:研究与应用现状  

Research and application of tissue-engineered tendon for repairing tendon sports injury

作　　者：谭贡霞[1] 张允蚌[2] 

机构地区：[1]赣南医学院康复学院,江西省赣州市341000 [2]赣南师范学院体育学院,江西省赣州市341000

出　　处：《中国组织工程研究与临床康复》2010年第12期2225-2228,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:总结和分析肌腱组织工程应用于肌腱运动损伤修复的研究现状。方法:以"tissue engineering,artificial biocompatible tendon",为英文检索词,以"组织工程,肌腱"为中文检索词,计算机检索PubMed和万方数据库1994-01/2009-12的相关文献。纳入具有原创性,论点论据可靠的实验文章,排除重复性的研究,选择符合标准的33篇文献做进一步分析。结果:肌腱运动损伤后若未予以及时修复常会导致肢体功能障碍,组织工程化人工肌腱修复缺损肌腱可对肌腱缺损进行形态修复和功能重建,并达到永久性替代。目前,组织工程学研究进展迅速,但要真正应用于临床仍存在一些问题。文章就以下问题进行了讨论:①种子细胞的来源。②对材料选取及如何合理改进,从而塑造理想的器官形状三维支架材料。③如何模拟体内环境,在体外构建肌腱组织。④如何使制造出来的组织工程肌腱有更好的生物力学性能。结论:如何在体外利用生物反应器模拟体内环境,进行组织工程化肌腱的构建,将是未来的研究方向。OBJECTIVE：To summarize and analyze the application of tissue-engineered tendon for repairing tendon sports injury.METHODS：Relative articles were retrieved from Pubmed and Wanfang databases with the Keywords of ＂tissue engineering,artificial biocompatible tendon＂ in both Chinese and English between January 1994 and December 2009.Original and reliable experimental articles were included,while duplicated research was excluded.A total of 33 literatures were included in the final analysis.RESULTS：Tendon sports injury might cause limb disturbance,while tissue-engineered artificial tendon could repair tendon defect immediately and reconstruct the morphology and function,and even the artificial tendon would replace permanently.Recently,tissue engineering research develops rapidly;however,it still has some problems for clinical application,including source of seed cells,collection and reasonable modification of materials for establishing an ideal organ-shaped 3D scaffold,simulation of internal environment and in vitro construction of tendon tissue,and establishment of tissue-engineered tendon with great biomechanical property.CONCLUSION：Stimulating internal environment using bioreactor to construct tissue-engineered tendon will be a hot topic in the future.

关 键 词：组织工程 肌腱 运动损伤 修复 材料 

分 类 号：R318[医药卫生—生物医学工程]