降钙素原在感染性疾病中的临床意义  

Clinical Significance of Procalcitonin in Infectious Diseases

作　　者：邓历[1] 

机构地区：[1]江苏省无锡市传染病医院,214005

出　　处：《职业与健康》2010年第7期823-824,共2页Occupation and Health

摘　　要：目的探讨感染性疾病患者血清中降钙素原(PCT)指标变化。方法运用免疫胶体金半定量快速实验方法,检测200例感染性患者及50例健康者血清中PCT水平。结果PCT水平分<0.5、0.5～2.0、2.0～10.0和>10ng/ml4个等级。设PCT>0.5ng/ml为阳性值。在病毒感染性疾病组中,阳性率为10%,其浓度以0.5～2.0ng/ml为主。细菌性感染组阳性率为78.4%,其浓度以0.5～2.0和2.0～10.0ng/ml为主。重度感染组阳性率为95.2%,其浓度显著增高。与正常对照组及病毒感染组比较,细菌感染组及重度感染组血清中PCT水平差异有统计学意义(P<0.01)。结论病毒性感染疾病患者血清中PCT水平不升高或轻度升高,而细菌性感染患者及重度感染患者血清中PCT水平则明显升高,尤其以重度感染组患者为甚。[Objective]To investigate the variation of procalcitonin （PCT） in patients with infectious diseases.[Methods]Immuno-colloidal gold semi-quantitative rapid test method was adopted to detect serum PCT levels of 200 cases of infectious diseases and 50 healthy persons.[Results]The level of PCT was divided 4 grades,that was 0. 5 ng/ml,0.5~2.0 ng/ml,2.0~10.0 ng/ml and 10 ng/ml. PCT0.5 ng/ml was set as positive values. In viral infectious disease group,the positive rate was 10%,the concentration was the main of 0.5~2.0 ng/ml. The positive rate of bacterial infection group was 78.4%,the concentration was the main of 0.5~2.0 ng/ml and 2.0~10.0 ng/ml. The positive rate of severe infection was 95.2%; its concentration increased significantly. Compared with the normal control group and infected group,serum PCT levels of bacterial infection and severe infection were significant different（P0.01）.[Conclusion]Serum PCT levels V does not elevate or mildly elevates in viral infection patients,while that increases significantly in the bacterial infection patients and severe infection patients,especially in patients with severe infection.

关 键 词：降钙素原(PCT) 感染性疾病 

分 类 号：R453[医药卫生—治疗学]