蜂毒有效成分分离及其抗血栓作用的研究  

Study on Isolation of Bee Venom's Effectual Components and Their Effects on Thrombus

作　　者：刘自元[1] 孟令瑜[1] 吴围屏[1] 林玲[1] 于永强 

机构地区：[1]山东省医学科学院,济南250062

出　　处：《中国生化药物杂志》1998年第6期381-383,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：蜂毒经DEAE－Senhadex－A50柱层析，获得蜂毒Ⅰ峰液，经体外抗血栓试验、大白鼠体内微循环实验、血栓高危人群血液流变学试验，表明蜂毒Ⅰ峰液具有明显的抗血栓形成作用。可能是由于蜂毒的有效成分蜂毒肽等改变了红细胞膜的流动性，降低了全血粘度和血浆粕度及血球的聚集程度，加快了红细胞的电泳速度，达到了活血化瘀的作用。Bee venom were chromatogographied by DEAE-Spephadex- A50,bee venom Ⅰ peak component was obtained. Bee venom Ⅰ was studied with anti-thrombosis test in vitro,rat microcirculation in vivo,blood rheology of thrombus high-risk human group,the results indicated the bee venom peak Ⅰ had anti-thrombosis effect significantly.

关 键 词：蜂毒 血栓 微循环 血液流变学 药理 

分 类 号：R973.2[医药卫生—药品] R931.74[医药卫生—药学]