子痫前期患者IGF-1水平与围产儿结局的相关性研究  

Correlation Between IGF-1 Level and Perinatal Outcome in Patients with Preeclampsia

作　　者：丁华[1] 黄丽萍[1] 刘和录[1] 张荣贵[1] 梁巧玲[1] 

机构地区：[1]广州医学院附属深圳沙井医院,广东深圳518104

出　　处：《实用预防医学》2010年第4期654-656,共3页Practical Preventive Medicine

基　　金：深圳市宝安区科研立项课题(2008202)

摘　　要：目的探讨子痫前期患者IGF-1水平与围产儿结局的相关性。方法选择正常晚期孕妇28例为对照组,轻、重度子痫前期孕妇各15例为研究组,分别于分娩前抽取孕妇静脉血,分娩时留取新生儿脐静脉血和羊水,同时记录新生儿出生体重、Apgar评分及胎盘重量等,应用酶联免疫吸附试验(ELISA),检测孕妇血、脐血及羊水中IGF-1水平,分析子痫前期中IGF-1水平与围产儿结局的相关性。结果(1)随着子痫前期病情严重程度的增加,IGF-1水平呈下降趋势,重度子痫前期组IGF-1水平明显低于轻度子痫前期组,轻度子痫前期组明显低于正常对照组,统计结果差异有统计学意义(P<0.01)。(2)随着IGF-1水平的下降,重度子痫前期的新生儿出生时平均体重、Apgar评分、胎盘重量均显著低于正常对照组,统计结果差异有统计学意义(P<0.01);FGR发生率、围产儿死亡率明显高于正常对照组,其结果差异有统计学意义(P<0.01)。结论子痫前期患者IGF-1水平变化为胎儿预后提供了一种监测手段,重度子痫前期IGF-1水平显著降低,并且围产儿不良结局发生率较高。Objective To investigate the correlation between IGF-1 level and perinatal outcome in patients with preeclampsia.Methods Twenty-eight cases of normal late pregnant women were selected as control group,and 30 cases of pregnant women with mild （n=15） and severe （n=15） preeclampsia were analyzed as study group.Venous blood of pregnant women was collected before delivery.Umbilical cord blood and amniotic fluid were collected.Neonatal birth weight,Apgar score and placental weight were recorded simultaneously.IGF-1 level was detected with enzyme-linked immunosorbent assay （ELISA） in maternal blood,umbilical cord blood and amniotic fluid.The correlation between IGF-1 level and perinatal outcome in pregnant women with preeclampsia was analyzed.Results （1） IGF-1 level declined with the severity of preeclampsia increased.IGF-1 level of severe preeclampsia group was significantly lower than that of mild preeclampsia group,IGF-1 level of mild preeclampsia group was significantly lower than that of control group,and the difference was statistically significant （P0.01）.（2） With the IGF-1 level declined,the average birth weight,Apgar score,and placental weight in severe preeclampsia group were significantly lower than those of control group,and the difference was statistically significant （P0.01）.The incidence rate of fetal growth restriction （FGR） and perinatal mortality rate in severe preeclampsia group were significantly higher than those of normal control group,and the difference was statistically significant （P0.01）.Conclusions The change of IGF-1 level in pregnant woman with preeclampsia provides a monitoring means for the prognosis of the fetus.IGF-1 level in pregnant woman with severe preeclampsia declines significantly,moreover,the incidence of perinatal adverse outcome is higher.

关 键 词：子痫前期 孕妇血 脐血 羊水 胰岛素样生长因子Ⅰ 围产儿结局 

分 类 号：R714.7[医药卫生—妇产科学]