华容县1268例狂犬病疫苗接种后抗体水平分析  

Analysis on Antibody Levels of 1,268 Individuals After Being Inoculated Rabies Vaccine in Huarong

作　　者：熊新华[1] 

机构地区：[1]湖南省华容县疾病预防控制中心,湖南华容414200

出　　处：《实用预防医学》2010年第4期765-766,共2页Practical Preventive Medicine

摘　　要：目的了解不同年龄、性别、季节、采血时间、免疫程序等因素对免疫效果的影响。方法采用间接ELISA法对2007年1月-2009年11月期间华容县疾病预防控制中心预防医学门诊采集到的检测狂犬病毒抗体的1268份血清标本进行检测。结果接种疫苗后,抗体的阳性率为93.7%,除季节、性别因素外,年龄、免疫程序采血时间均为血清抗体水平的影响因素。结论人被动物致伤后接种狂犬病疫苗,可获得有效的保护,免疫后检测血清抗体水平十分重要,对暂未产生抗体者要及时加强免疫提高抗体阳转率,严重咬伤者注射抗狂犬血清后,再进行全程免疫可获得满意的免疫效果,同时要注意采血时间对抗体检测结果也会产生影响。Objective To investigute the impact of age,sex,season,sampling time and procedure on the immunization effect.Methods The indirect ELISA method was used to detect the antibody levels of 1,268 serum samples which were collected by Huarong CDC from January,2007 to November,2009.Results The positive rate of antibody against the rabies virus was 93.7%.Age,procedure and sampling time were the affecting factors of antibody level in serum except sex and season.Conclusions Most of people can be protected after being inoculated the rabies vaccine when being harmed by animals.It is important to detect the antibody level after immunization.Those who have not produced the antibody have to strengthen the immunity promptly and enhance the immune body to transfer positive rate.The severe patient could get a satisfied immunizing effect after being injected anti-rabies serum and 5-dose rabies vaccines.The sampling time is an affecting factor for the determination of human anti-rabies virus antibody.

关 键 词：狂犬病疫苗 抗体水平 免疫效果 

分 类 号：R186[医药卫生—流行病学]