非甾体类抗炎药致上消化道出血的临床分析  

Clinical analysis of non-steroidal anti-inflammatory drugs induced upper gastrointestinal bleeding

作　　者：张彭[1] 潘珅[2] 杨颖[3] 王孟春[3] 

机构地区：[1]沈阳市第五人民医院消化内科,沈阳110023 [2]中国医科大学94期影像系,沈阳110001 [3]中国医科大学附属盛京医院消化内科,沈阳110004

出　　处：《实用药物与临床》2010年第2期111-112,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨非甾体类抗炎药(NSAIDs)致上消化道出血的临床特点。方法对182例上消化道出血患者的临床资料进行回顾性分析,根据出血前1周内是否服用过NSAIDs,将患者分为NSAIDs组(43例)和非NSAIDs组(139例)。对比分析两组患者的临床资料。结果两组比较,NSAIDs组与非NSAIDs组在年龄、溃疡类型等方面差异有统计学意义。结论应加强对NSAIDs相关性上消化道出血临床特点的认识,以减少NSAIDs的不良反应。Objective To analyze the clinical features of non-steroidal anti-inflammatory drugs（NSAIDs）induced upper gastrointestinal bleeding.Methods Clinical data of 182 patients with upper gastrointestinal bleeding were analyzed retrospectively.Patients were divided into NSAIDs group（n=43）and non NSAIDs group（n=139）based on whether or not NSAIDs were taken within 7 days before the onset of bleeding.Results There were significantly differences between NSAIDs group and non NSAIDs group in age of patients and types of ulcer.Conclusion In order to decrease the occurrence of NSAIDs complication,the clinical characteristics of NSAIDs induced upper gastrointestinal bleeding should be better understood.

关 键 词：非甾体抗炎药 胃肠道黏膜损伤 

分 类 号：R595.3[医药卫生—内科学] R573.2[医药卫生—临床医学]