工艺控制对复方丹参片保护麻醉犬心肌梗死的影响  

Effects of Danshen Tablets Under Process Control on Myocardial Infarction Caused by Coronary Artery Ligation of Anesthetic Dogs

作　　者：黄琳[1] 林青[1] 肖晓丽[1] 李楚源[1] 

机构地区：[1]广州白云山和记黄埔中药有限公司,广东广州510515

出　　处：《中国现代中药》2010年第4期30-33,共4页Modern Chinese Medicine

基　　金：广州市科技局科技攻关计划项目(2004Z1-E5021)

摘　　要：目的:控制工艺条件制备了有效成分含量不同的复方丹参片,观察其对麻醉犬冠脉结扎所致心肌梗死的保护作用。方法:采用麻醉犬冠脉结扎导致心肌梗死的方法造模,观察给药前后的影响。结果:复方丹参片工艺A组、工艺B组能降低冠脉结扎所致心肌梗死麻醉犬的HR和心肌耗氧量,复方丹参片工艺B组能降低冠脉结扎所致心肌梗死麻醉犬的DAP、MAP,抑制冠脉结扎所致的动静脉氧差增加。结论:工艺参数的调整影响复方丹参片有效成分的含量,有效成分达到一定量时,可明显缓解心肌缺血症状。Objective： Prepared Danshen tablets under different process control plans are to be observed protective effects on acute myocardial infarction of dogs. Methods： To make the model of acute myocardial infarction of dogs by coronary ligation and to observe changes before and after of administration. Results： Danshen tablets have the protective effect on acute myocardial infarction. Both processes A and B appeared to decrease heart rate （HR） and myocardial oxygen consumption of the animal models; Processes B decrease DAP, MAP and the increase of arteriove- nous oxygen difference. Conclusion： Danshen Tablets can markedly relieve myocardial ischemia. The parameters of extraction impact on the content of the main effective constituents. The higher content of effective constituents induces the more remarkable protective effect.

关 键 词：复方丹参片 麻醉犬 心肌缺血 

分 类 号：R259.414[医药卫生—中西医结合]