经桡动脉冠状动脉造影对患者血清MDA、T-SOD水平的影响  

Impact of Transradial Approach on Serum MDA and T-SOD Levels in Patients

作　　者：吴宝[1] 刘红旭[1] 李爱勇[1] 

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《世界中西医结合杂志》2010年第3期214-216,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然基金资助项目(No.30873246)

摘　　要：目的观察经桡动脉冠状动脉造影(CAG)对患者血清丙二醛(MDA)、总超氧化物歧化酶(T-SOD)水平的影响。方法分别应用黄嘌呤氧化酶法和硫代巴比妥酸法,测定了121例经桡动脉CAG冠心病患者术前、术后血清中MDA水平及T-SOD活力。同期选择30例明确诊断为不稳定型心绞痛患者,检测其治疗前后血清中MDA、T-SOD水平作为对照。结果CAG术后较术前血清中MDA水平、T-SOD活力升高(P<0.05,P<0.01)。介入治疗患者治疗前后MDA、T-SOD水平比较,差异无统计学意义(P>0.05)。结论经桡动脉CAG可能造成轻度的内皮损伤,并激活了机体内源性保护机制。Objective To observe the impact of transradial approach（TRA）on serum MDA and T-SOD levels in patients.Methods Xanthine oxidase method and thiobarbituric acid method were used respectively to determine MDA level and T-SOD activity of 121 cases of coronary heart disease before and after TRA.Meanwhile,30 cases with definite diagnosis of unstable angina pectoris were selected as control group and MDA and T-SOD levels of them were detected in serum before and after treatment.Results After TRA,MDA level and T-SOD activity increased in serum as composed with those before surgery（P0.05,P0.01）.The comparison of MDA and T-SOD levels before and after intervention did not present significant statistical differences（P0.05）.Conclusion TRA may cause mild endothelial injury and activate endogenous protective mechanism in organism.

关 键 词：桡动脉 冠状动脉造影 丙二醛 总超氧化物歧化酶 血清 临床研究 

分 类 号：R816.2[医药卫生—放射医学]