应用1H-MRS技术结合LCmodel软件定量分析正常成人中央前回及海马脑代谢物浓度  

Absolute quantification of brain metabolite concentration of precentral gyrus and hippocampus of healthy adults using proton magnetic resonance spectroscopy and LCmodel

作　　者：成小芳[1] 曹震[1] 徐志锋[1] 肖叶玉[1] 沈智威[1] 庞丽[1] 郭绣琴[1] 吴仁华[1] 

机构地区：[1]广东省汕头大学医学院第二附属医院影像科,广东汕头515041

出　　处：《医学影像学杂志》2010年第3期300-303,共4页Journal of Medical Imaging

基　　金：国家自然科学基金重点项目(编号:30930027);广东省自然科学基金项目(815503102000032)

摘　　要：目的:本研究通过利用氢质子磁共振频谱(1H-MRS)技术结合LCmodel软件分析正常健康成人中央前回及海马的脑代谢物特征及其浓度。方法:正常健康志愿者9名,无神经系统疾病史。用GE 1.5T Signa HDX超导磁共振扫描仪,采用刺激回波采样方式(STEAM)对大脑左侧中央前回及海马区的脑代谢物进行测定,并利用LCmodel软件对采集的数据进行后处理及定量分析。结果:海马及中央前回Cho及MI的浓度具有统计学差异(P<0.05),两者在海马浓度均高于中央前回。两部位的Cr及GLX浓度无统计学差异。中央前回(7.608±1.20)mmol/L所获得的NAA浓度相对高于海马(5.841±1.38)mmol/L。结论:中央前回及海马之间的脑代谢物浓度存在一定的差异,中央前回CHO及MI浓度低于海马,两部位的Cr及GLX浓度无显著差异。Objective：To study the metabolite characteristic and concentration of precentral gyrus and hippocampus using proton magnetic resonance spectroscopy combined with LCmodel software.Methods：1H-MRS data of 9 healthy adults were collected by GE 1.5-T MR scanner,using STEAM sequence.The voxels were located over the left precentral gyrus and hippocampus.The data of spectra were postprocessed using LCModel software.Results：Results showed significantly higher Cho and MI in hippocampus than those in precentral gyrus while no significant difference for Cr and GLX concentrations in these two locations was observed.We observed relatively higher NAA concentration in precentral gyrus（7.608±1.20） mmol/L than in hippocampus（5.841±1.38） mmol/L.Conclusion：There are variations of the metabolites between precentral gyrus and hippocampus.Cho and MI are higher in hippocampus than in precentral gyrus.No statistical difference for Cr and GLX concentration is observed in these two locations.

关 键 词：质子磁共振频谱 LCMODEL 中央前回 海马 代谢物 定量 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338[医药卫生—诊断学]