重症遗尿症药物治疗停药方式的对照研究  

Comparison of therapeutic effects in severe nocturia: gradual versus immediate drug withdrawal

作　　者：唐芳政[1,2] 刘亚兰 文飞球[1,2] 张朝霞 

机构地区：[1]暨南大学附属第二临床学院 [2]深圳市人民医院儿科,广东深圳518020

出　　处：《中国当代儿科杂志》2010年第3期198-200,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的探讨不同停药方式对重症遗尿症预后的影响。方法97例重症遗尿症患儿随机分为对照组(n=47)和观察组(n=50),给予同样的药物治疗12周,但采取不同的停药方式。对照组在疗程结束后立即停药;观察组在疗程结束后行阶梯式减量。观察两组自完全停药3个月后遗尿的次数。结果两组在治疗期间治愈率均为100%。停药3个月后对照组治愈率为60%(28人),观察组为92%(46人),治愈率差异有统计学意义(P<0.01)。两组药物副作用和患儿依从性差异无统计学意义。结论重症遗尿症的患儿进行同样的药物治疗方案,但不同的停药方式可导致不同的预后,阶梯式减量停药方式明显优于立即停药的方式。Objective To investigate possible differences in the prognosis in children with severe nocturia who received different drug withdrawal schedules.Methods Ninety-seven children with severe nocturia were randomly assigned to two groups： control （n=47） and observed （n=50）. The control group accepted drug withdrawal immediately, while the observed group accepted dose tapering gradually after a 12-week treatment course. The frequency of enuresis was observed three months after complete drug withdrawal.Results During the treatment, the frequency of enuresis in all of children from both the control and the observed groups was reduced by over 90%. Forty-six children （92%） from the observed group showed the frequency of enuresis was reduced by over 90%, but 28 children （60%） from the control group （P0.01） three months after the complete drug withdrawal. There were no significant differences in the adverse effect and the medication compliance between the two groups.Conclusions The different schedules of drug withdrawal may lead to different prognosis, and the schedule of gradual drug withdrawal may be superior to the immediate one in children with nocturnal enuresis.

关 键 词：遗尿症 治疗 儿童 

分 类 号：R726.9[医药卫生—儿科]