补肾方剂对糖尿病大鼠牙周炎的疗效观察  

Effects of Tonifying Kidney Recipes on Periodontitis in Diabetes Rats

作　　者：谢景朝[1] 于静[1] 赵晓军[1] 陈靖[1] 张玉杰[1] 赵发银 胡永权[1] 张聚华[1] 

机构地区：[1]石家庄市第二医院口腔科,石家庄050051

出　　处：《临床误诊误治》2010年第4期311-313,共3页Clinical Misdiagnosis & Mistherapy

基　　金：石家庄市科技支撑计划项目(编号091461273)

摘　　要：目的观察补肾方剂对糖尿病大鼠牙周炎的治疗效果。方法选择60只大鼠建立糖尿病牙周炎模型,按照给药的不同分为单纯牙周炎组(不给药)、灌喂中药组(补肾方剂)、灌喂氨基胍(AG)组;同时选择16只正常大鼠作为对照组,给药4周、6周后均制作组织切片,观察牙周组织形态结构的变化,测定牙龈中一氧化氮(NO)含量。结果灌喂中药组的结缔组织附着丧失量、牙槽骨高度丧失量、牙龈组织中NO的含量均明显低于其他糖尿病牙周炎组,差异有统计学意义(P<0.05)。结论补肾方剂对促进糖尿病牙周炎牙周组织的修复,降低NO含量的作用优于AG。Objective To observe the effect of Tonifying Kidney Recipes（TKR） on diabetes periodontitis in rats.Methods 60 healthy rats were chosen to make the diabetes periodontitis models and divided into diabetes group,TKR group,AG group and control group（n=16）.Tissue slices were taken 4 and 6 weeks after administration.The gingiva of the left first maxillary molars was cut to measurate the amount of NO.Results The loss of connective tissue attachment and alveolar bone height and the amount of NO were lower in TKR group than in DP group with significant difference（P0.05）.Conclusion TKR can play a role in promoting the restoration of periodontium and reducing in the amount of NO.The treatment effect of TKR is better than that of AG.

关 键 词：补肾方剂 氨基胍 糖尿病 牙周炎 动物实验 

分 类 号：R285.5[医药卫生—中药学]